Role of 18F-DOPA PET/CT Imaging in Congenital Hyperinsulinism

Overview

Journal Rev Endocr Metab Disord

Publisher Springer

Specialty Endocrinology

Date 2010 Sep 30

PMID 20878481

Citations 12

Authors

Dunia Ismail

Khalid Hussain

Affiliations

Soon will be listed here.

Abstract

Congenital hyperinsulinism is a leading cause of severe hypoglycaemia in the newborn period. There are two (diffuse and focal) histological subtypes of congenital hyperinsulinism. The diffuse form affects the entire pancreas and if medically unresponsive will require a near total (95%-98%) pancreatectomy. The focal form affects only a small region of the pancreas (with the rest of the pancreas being normal in endocrine and exocrine function) and only requires a limited pancreatectomy. This limited section of the focal lesion has the potential for curing the patient. Thus the pre-operative differentiation of these two subgroups is extremely important. Recent advances in Fluorine-18-L-dihydroxyphenylalanine positron emission tomography ((18)F-DOPA PET/CT) have radically changed the clinical approach to patient with congenital hyperinsulinism. In most patients this novel imaging technique is able to offer precise pre-operative localisation of the focal lesion, thus guiding the extent of surgical resection.

Citing Articles

Hypoglycemia in Children: Major Endocrine-Metabolic Causes and Novel Therapeutic Perspectives.

Quarta A, Iannucci D, Guarino M, Blasetti A, Chiarelli F Nutrients. 2023; 15(16).

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Laparoscopic Surgery for Focal-Form Congenital Hyperinsulinism Located in Pancreatic Head.

Wen Z, Wang J, Liang Q, Chang X, Zhang W, Niu H Front Pediatr. 2022; 10:919238.

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Variation in Glycemic Outcomes in Focal Forms of Congenital Hyperinsulinism-The UK Perspective.

Dastamani A, Yau D, Gilbert C, Morgan K, De Coppi P, Craigie R J Endocr Soc. 2022; 6(6):bvac033.

PMID: 35592516 PMC: 9113085. DOI: 10.1210/jendso/bvac033.

Genotype and phenotype analysis of a cohort of patients with congenital hyperinsulinism based on DOPA-PET CT scanning.

Ni J, Ge J, Zhang M, Hussain K, Guan Y, Cheng R Eur J Pediatr. 2019; 178(8):1161-1169.

PMID: 31218401 PMC: 6647509. DOI: 10.1007/s00431-019-03408-6.

Congenital Hyperinsulinism: Diagnosis and Treatment Update.

Demirbilek H, Hussain K J Clin Res Pediatr Endocrinol. 2017; 9(Suppl 2):69-87.

PMID: 29280746 PMC: 5790328. DOI: 10.4274/jcrpe.2017.S007.

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