Increased Cancer Risks for Relatives of Very Early-onset Breast Cancer Cases with and Without BRCA1 and BRCA2 Mutations

Overview

Journal Br J Cancer

Specialty Oncology

Date 2010 Sep 30

PMID 20877337

Citations 15

Authors

G S Dite

A S Whittemore

J A Knight

E M John

R L Milne

I L Andrulis

M C Southey

M R E McCredie

G G Giles

A Miron

A I Phipps

D W West

J L Hopper

Affiliations

Soon will be listed here.

Abstract

Background: Little is known regarding cancer risks for relatives of women with very early-onset breast cancer.

Methods: We studied 2208 parents and siblings of 504 unselected population-based Caucasian women with breast cancer diagnosed before age 35 years (103 from USA, 124 from Canada and 277 from Australia), 41 known to carry a mutation (24 in BRCA1, 16 in BRCA2 and one in both genes). Cancer-specific standardised incidence ratios (SIRs) were estimated by comparing the number of affected relatives (50% verified overall) with that expected based on incidences specific for country, sex, age and year of birth.

Results: For relatives of carriers, the female breast cancer SIRs were 13.13 (95% CI 6.57-26.26) and 12.52 (5.21-30.07) for BRCA1 and BRCA2, respectively. The ovarian cancer SIR was 12.38 (3.1-49.51) for BRCA1 and the prostate cancer SIR was 18.55 (4.64-74.17) for BRCA2. For relatives of non-carriers, the SIRs for female breast, prostate, lung, brain and urinary cancers were 4.03 (2.91-5.93), 5.25 (2.50-11.01), 7.73 (4.74-12.62), 5.19 (2.33-11.54) and 4.35 (1.81-10.46), respectively. For non-carriers, the SIRs remained elevated and were statistically significant for breast and prostate cancer when based on verified cancers.

Conclusion: First-degree relatives of women with very early-onset breast cancer are at increased risk of cancers not explained by BRCA1 and BRCA2 mutations.

Citing Articles

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Segregation analysis of 17,425 population-based breast cancer families: Evidence for genetic susceptibility and risk prediction.

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Bioinformatic analysis reveals the key pathways and genes in early-onset breast cancer.

Cui C, Li L, Zhen J Med Oncol. 2018; 35(5):67.

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