Quantitative Assessment of Diffusion-weighted MR Imaging in Patients with Primary Rectal Cancer: Correlation with FDG-PET/CT

Overview

Journal Mol Imaging Biol

Publisher Springer

Specialties Molecular Biology
Radiology

Date 2010 Sep 28

PMID 20872077

Citations 35

Authors

Jing Gu

Pek-Lan Khong

Silun Wang

Queenie Chan

Wailun Law

Jingbo Zhang

Affiliations

Soon will be listed here.

Abstract

Purpose: The aim of the study was to assess correlations between parameters on diffusion-weighted imaging and 2-deoxy-2-[(18)F]fluoro-D-glucose-positron emission tomography/computed tomography (FDG-PET/CT) in rectal cancer.

Procedures: Thirty-three consecutive patients with pathologically confirmed rectal adenocarcinoma were included in this study. Apparent diffusion coefficient (ADC) maps were generated to calculate ADC(mean) (average ADC), ADC(min) (lowest ADC), tumor volume, and total diffusivity index (TDI). PET/CT exams were performed within 1 week of magnetic resonance imaging. Standardized uptake values (SUVs) were normalized to the injected FDG dose and body weight. SUV(max) (maximum SUV), SUV(mean) (average SUV), tumor volume, and total lesion glycolysis (TLG) were calculated using a 50% threshold.

Results: Significant negative correlations were found between ADC(min) and SUV(max) (r = -0.450, p = 0.009), and between ADC(mean) and SUV(mean) (r = -0.402, p = 0.020). A significant positive correlation was found between TDI and TLG (r = 0.634, p < 0.001).

Conclusion: The significant negative correlations between ADC and SUV suggest an association between tumor cellularity and metabolic activity in primary rectal adenocarcinoma.

Citing Articles

Correlation of 3T Diffusion-weighted MRI and F-FDG-PET/CT in Liver Metastases: SUV Versus ADC.

Tanyeri A, Akbulut R, Nevai E, Yurekli Y Mol Imaging Radionucl Ther. 2025; 34(1):48-54.

PMID: 39918041 PMC: 11827527. DOI: 10.4274/mirt.galenos.2024.37431.

Evaluation of lesion contrast in the walk-through long axial FOV PET scanner simulated with XCAT anthropomorphic phantoms.

Dadgar M, Maebe J, Vandenberghe S EJNMMI Phys. 2024; 11(1):44.

PMID: 38722428 PMC: 11082126. DOI: 10.1186/s40658-024-00645-z.

Whole lesion histogram analysis of apparent diffusion coefficient predicts therapy response in locally advanced rectal cancer.

Jimenez de Los Santos M, Reyes-Perez J, Dominguez Osorio V, Villasenor-Navarro Y, Moreno-Astudillo L, Vela-Sarmiento I World J Gastroenterol. 2022; 28(23):2609-2624.

PMID: 35949349 PMC: 9254137. DOI: 10.3748/wjg.v28.i23.2609.

A decade of multi-modality PET and MR imaging in abdominal oncology.

Min L, Castagnoli F, Vogel W, Vellenga J, van Griethuysen J, Lahaye M Br J Radiol. 2021; 94(1126):20201351.

PMID: 34387508 PMC: 9328040. DOI: 10.1259/bjr.20201351.

Correlation between 18F-FDG PET/CT and diffusion-weighted MRI parameters in head and neck squamous cell carcinoma at baseline and after chemo-radiotherapy. A retrospective single institutional study.

Garau L, Manca G, Bola S, Aringhieri G, Faggioni L, Volterrani D Oral Radiol. 2021; 38(2):199-209.

PMID: 34133000 DOI: 10.1007/s11282-021-00545-3.

References

Nakamoto Y, Saga T, Fujii S . Positron emission tomography application for gynecologic tumors. Int J Gynecol Cancer. 2005; 15(5):701-9. DOI: 10.1111/j.1525-1438.2005.00245.x. View

Lordick F, Ott K, Krause B, Weber W, Becker K, Stein H . PET to assess early metabolic response and to guide treatment of adenocarcinoma of the oesophagogastric junction: the MUNICON phase II trial. Lancet Oncol. 2007; 8(9):797-805. DOI: 10.1016/S1470-2045(07)70244-9. View

Biehl K, Kong F, Dehdashti F, Jin J, Mutic S, El Naqa I . 18F-FDG PET definition of gross tumor volume for radiotherapy of non-small cell lung cancer: is a single standardized uptake value threshold approach appropriate?. J Nucl Med. 2006; 47(11):1808-12. View

Ueda S, Kondoh N, Tsuda H, Yamamoto S, Asakawa H, Fukatsu K . Expression of centromere protein F (CENP-F) associated with higher FDG uptake on PET/CT, detected by cDNA microarray, predicts high-risk patients with primary breast cancer. BMC Cancer. 2008; 8:384. PMC: 2631591. DOI: 10.1186/1471-2407-8-384. View

Even-Sapir E, Parag Y, Lerman H, Gutman M, Levine C, Rabau M . Detection of recurrence in patients with rectal cancer: PET/CT after abdominoperineal or anterior resection. Radiology. 2004; 232(3):815-22. DOI: 10.1148/radiol.2323031065. View

Kuwert T, Probst-Cousin S, Woesler B, Morgenroth C, LERCH H, Matheja P . Iodine-123-alpha-methyl tyrosine in gliomas: correlation with cellular density and proliferative activity. J Nucl Med. 1997; 38(10):1551-5. View

Kim B, Kim Y, Lee K, Yoon S, Cheon E, Kwon O . Localized form of bronchioloalveolar carcinoma: FDG PET findings. AJR Am J Roentgenol. 1998; 170(4):935-9. DOI: 10.2214/ajr.170.4.9530038. View

Herneth A, Guccione S, Bednarski M . Apparent diffusion coefficient: a quantitative parameter for in vivo tumor characterization. Eur J Radiol. 2003; 45(3):208-13. DOI: 10.1016/s0720-048x(02)00310-8. View

Taouli B, Vilgrain V, Dumont E, Daire J, Fan B, Menu Y . Evaluation of liver diffusion isotropy and characterization of focal hepatic lesions with two single-shot echo-planar MR imaging sequences: prospective study in 66 patients. Radiology. 2003; 226(1):71-8. DOI: 10.1148/radiol.2261011904. View

10.

Schoder H, Noy A, Gonen M, Weng L, Green D, Erdi Y . Intensity of 18fluorodeoxyglucose uptake in positron emission tomography distinguishes between indolent and aggressive non-Hodgkin's lymphoma. J Clin Oncol. 2005; 23(21):4643-51. DOI: 10.1200/JCO.2005.12.072. View

11.

Willinek W, Gieseke J, von Falkenhausen M, Neuen B, Schild H, Kuhl C . Sensitivity encoding for fast MR imaging of the brain in patients with stroke. Radiology. 2003; 228(3):669-75. DOI: 10.1148/radiol.2283020243. View

12.

Daisne J, Duprez T, Weynand B, Lonneux M, Hamoir M, Reychler H . Tumor volume in pharyngolaryngeal squamous cell carcinoma: comparison at CT, MR imaging, and FDG PET and validation with surgical specimen. Radiology. 2004; 233(1):93-100. DOI: 10.1148/radiol.2331030660. View

13.

Ashamalla H, Rafla S, Parikh K, Mokhtar B, Goswami G, Kambam S . The contribution of integrated PET/CT to the evolving definition of treatment volumes in radiation treatment planning in lung cancer. Int J Radiat Oncol Biol Phys. 2005; 63(4):1016-23. DOI: 10.1016/j.ijrobp.2005.04.021. View

14.

Downey R, Akhurst T, Ilson D, Ginsberg R, Bains M, Gonen M . Whole body 18FDG-PET and the response of esophageal cancer to induction therapy: results of a prospective trial. J Clin Oncol. 2003; 21(3):428-32. DOI: 10.1200/JCO.2003.04.013. View

15.

Koh D, Collins D . Diffusion-weighted MRI in the body: applications and challenges in oncology. AJR Am J Roentgenol. 2007; 188(6):1622-35. DOI: 10.2214/AJR.06.1403. View

16.

Berger K, Nicholson S, Dehdashti F, Siegel B . FDG PET evaluation of mucinous neoplasms: correlation of FDG uptake with histopathologic features. AJR Am J Roentgenol. 2000; 174(4):1005-8. DOI: 10.2214/ajr.174.4.1741005. View

17.

Gu J, Yamamoto H, Fukunaga H, Danno K, Takemasa I, Ikeda M . Correlation of GLUT-1 overexpression, tumor size, and depth of invasion with 18F-2-fluoro-2-deoxy-D-glucose uptake by positron emission tomography in colorectal cancer. Dig Dis Sci. 2006; 51(12):2198-205. DOI: 10.1007/s10620-006-9428-2. View

18.

Bos R, van der Hoeven J, van der Wall E, van der Groep P, van Diest P, Comans E . Biologic correlates of (18)fluorodeoxyglucose uptake in human breast cancer measured by positron emission tomography. J Clin Oncol. 2002; 20(2):379-87. DOI: 10.1200/JCO.2002.20.2.379. View

19.

Takahara T, Imai Y, Yamashita T, Yasuda S, Nasu S, Van Cauteren M . Diffusion weighted whole body imaging with background body signal suppression (DWIBS): technical improvement using free breathing, STIR and high resolution 3D display. Radiat Med. 2004; 22(4):275-82. View

20.

Herholz K, Pietrzyk U, Voges J, Schroder R, Halber M, Treuer H . Correlation of glucose consumption and tumor cell density in astrocytomas. A stereotactic PET study. J Neurosurg. 1993; 79(6):853-8. DOI: 10.3171/jns.1993.79.6.0853. View