Lipid Mediators in Acne

Overview

Journal Mediators Inflamm

Publisher Wiley

Specialties Biochemistry
Pathology

Date 2010 Sep 28

PMID 20871834

Citations 36

Authors

Monica Ottaviani

Emanuela Camera

Mauro Picardo

Affiliations

Soon will be listed here.

Abstract

Multiple factors are involved in acne pathogenesis, and sebum secretion is one of the main ones. The role sebum plays in acne development has not been completely elucidated yet; however, increasing amounts of data seem to confirm the presence of alterations in sebum from acne patients. Altered ratio between saturated and unsaturated fatty acids has been indicated as an important feature to be considered in addition to the altered amount of specific fatty acids such as linoleic acid. Furthermore, particular attention has been focused on squalene peroxide that seems to be able to induce an inflammatory response beyond cytotoxicity and comedones formation. Moreover, recent data suggest that lipid mediators are able to interfere with sebocytes differentiation and sebogenesis through the activation of pathways related to peroxisome proliferators-activated receptors. Understanding the factors and mechanisms that regulate sebum production is needed in order to identify novel therapeutic strategies for acne treatment.

Citing Articles

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The Role of Linoleic Acid in Skin and Hair Health: A Review.

Wang X, Jia Y, He H Int J Mol Sci. 2025; 26(1.

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Significance of host antimicrobial peptides in the pathogenesis and treatment of acne vulgaris.

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A New Generation of Postbiotics for Skin and Scalp: In Situ Production of Lipid Metabolites by .

Pagac M, Gempeler M, Campiche R Microorganisms. 2024; 12(8).

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New Insights into the Role of PPARγ in Skin Physiopathology.

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