Clinical and Cytogenetic Analysis of Human Anemias from Jammu Region of Jammu and Kashmir State

Overview

Journal Asian J Transfus Sci

Specialty Hematology

Date 2010 Sep 23

PMID 20859508

Citations 1

Authors

Upma

Parvinder Kumar

T R Raina

Kuldeep Sharma

Subash Gupta

Affiliations

Soon will be listed here.

Abstract

Background: Anemias are the blood disorders characterized by reduction in the number of circulating red blood cells, the amount of hemoglobin, or the volume of packed red cells in blood. Chromosomal aberrations have often been reported from the bone marrow as well as cultured lymphocytes of the anemic patients.

Aims: The aims of the study were to find out the commonest type of anemia occurring in the population of Jammu, India and to find out the chromosomal changes involved in the disorder.

Material And Methods: Present study has been carried out on the bone marrow samples from 53 clinically diagnosed anemic patients. Cytogenetic study was carried out on slides prepared from these samples. Noncytogenetic factors like age, sex, religion, blood groups, family history of anemia, socioeconomic status, etc. have also been included in the study.

Results: Megaloblastic anemia was found to be the commonest type of anemia. Centromere stretching, chromatid breaks, gaps, and elongation of chromosomes were recorded in patients with megaloblastic anemia and combined deficiency anemia. However, structural changes and numerical changes were totally absent.

Conclusion: The commonest anemia among the people of Jammu region is megaloblastic anemia and its prevalence is increasing every year. Also, megaloblastic anemia is always associated with reversible cytogenetic changes.

Citing Articles

Review: Understanding Rare Genetic Diseases in Low Resource Regions Like Jammu and Kashmir - India.

Angural A, Spolia A, Mahajan A, Verma V, Sharma A, Kumar P Front Genet. 2020; 11:415.

PMID: 32425985 PMC: 7203485. DOI: 10.3389/fgene.2020.00415.

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