MicroRNA in Lung Cancer

Overview

Journal Br J Cancer

Specialty Oncology

Date 2010 Sep 23

PMID 20859290

Citations 115

Authors

P-Y Lin

S-L Yu

P-C Yang

Affiliations

Soon will be listed here.

Abstract

MicroRNAs (miRNAs) are small non-protein-coding RNAs that function as endogenous negative gene regulators. Dysfunctions of miRNAs are frequently found in malignancies, including lung cancer. In this review, we summarise the current understanding of miRNAs in lung cancer tumourigenesis, and highlight their potential in overcoming drug resistance, abetting histological sub-classification techniques, and serving as biomarkers for lung cancer risk stratification and outcome prediction.

Citing Articles

Graph Convolutional Network with Neural Collaborative Filtering for Predicting miRNA-Disease Association.

Ha J Biomedicines. 2025; 13(1.

PMID: 39857720 PMC: 11762804. DOI: 10.3390/biomedicines13010136.

Improved lung cancer classification by employing diverse molecular features of microRNAs.

Guo S, Mao C, Peng J, Xie S, Yang J, Xie W Heliyon. 2024; 10(4):e26081.

PMID: 38384512 PMC: 10878959. DOI: 10.1016/j.heliyon.2024.e26081.

Exploring the interplay between methylation patterns and non-coding RNAs in non-small cell lung cancer: Implications for pathogenesis and therapeutic targets.

Yang M, Hu X, Tang B, Deng F Heliyon. 2024; 10(2):e24811.

PMID: 38312618 PMC: 10835372. DOI: 10.1016/j.heliyon.2024.e24811.

Regulatory Role of circRNA-0067835 in Behcet Disease through Targeting Micro RNA-155: Implication of and .

El-Din S, Rashed L, Saeed Mohamed D, Eissa M, Hamed R, Elsayed Hussein R Rep Biochem Mol Biol. 2023; 12(1):195-204.

PMID: 37724157 PMC: 10505462. DOI: 10.52547/rbmb.12.1.195.

Lung cancer associated with combustion particles and fine particulate matter (PM) - The roles of polycyclic aromatic hydrocarbons (PAHs) and the aryl hydrocarbon receptor (AhR).

Holme J, Vondracek J, Machala M, Lagadic-Gossmann D, Vogel C, Le Ferrec E Biochem Pharmacol. 2023; 216:115801.

PMID: 37696458 PMC: 10543654. DOI: 10.1016/j.bcp.2023.115801.

References

Yu S, Chen H, Chang G, Chen C, Chen H, Singh S . MicroRNA signature predicts survival and relapse in lung cancer. Cancer Cell. 2008; 13(1):48-57. DOI: 10.1016/j.ccr.2007.12.008. View

Hammond S, Bernstein E, Beach D, Hannon G . An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells. Nature. 2000; 404(6775):293-6. DOI: 10.1038/35005107. View

Lebanony D, Benjamin H, Gilad S, Ezagouri M, Dov A, Ashkenazi K . Diagnostic assay based on hsa-miR-205 expression distinguishes squamous from nonsquamous non-small-cell lung carcinoma. J Clin Oncol. 2009; 27(12):2030-7. DOI: 10.1200/JCO.2008.19.4134. View

Rosell R, Moran T, Queralt C, Porta R, Cardenal F, Camps C . Screening for epidermal growth factor receptor mutations in lung cancer. N Engl J Med. 2009; 361(10):958-67. DOI: 10.1056/NEJMoa0904554. View

Diederichs S, Haber D . Dual role for argonautes in microRNA processing and posttranscriptional regulation of microRNA expression. Cell. 2007; 131(6):1097-108. DOI: 10.1016/j.cell.2007.10.032. View

Okamura K, Hagen J, Duan H, Tyler D, Lai E . The mirtron pathway generates microRNA-class regulatory RNAs in Drosophila. Cell. 2007; 130(1):89-100. PMC: 2729315. DOI: 10.1016/j.cell.2007.06.028. View

Chin L, Ratner E, Leng S, Zhai R, Nallur S, Babar I . A SNP in a let-7 microRNA complementary site in the KRAS 3' untranslated region increases non-small cell lung cancer risk. Cancer Res. 2008; 68(20):8535-40. PMC: 2672193. DOI: 10.1158/0008-5472.CAN-08-2129. View

Eulalio A, Huntzinger E, Izaurralde E . Getting to the root of miRNA-mediated gene silencing. Cell. 2008; 132(1):9-14. DOI: 10.1016/j.cell.2007.12.024. View

Calin G, Croce C . MicroRNA signatures in human cancers. Nat Rev Cancer. 2006; 6(11):857-66. DOI: 10.1038/nrc1997. View

10.

Schaefer U, Voloshanenko O, Willen D, Walczak H . TRAIL: a multifunctional cytokine. Front Biosci. 2007; 12:3813-24. DOI: 10.2741/2354. View

11.

Denli A, Tops B, Plasterk R, Ketting R, Hannon G . Processing of primary microRNAs by the Microprocessor complex. Nature. 2004; 432(7014):231-5. DOI: 10.1038/nature03049. View

12.

Cho W, Chow A, Au J . Restoration of tumour suppressor hsa-miR-145 inhibits cancer cell growth in lung adenocarcinoma patients with epidermal growth factor receptor mutation. Eur J Cancer. 2009; 45(12):2197-206. DOI: 10.1016/j.ejca.2009.04.039. View

13.

Reinhart B, Slack F, Basson M, Pasquinelli A, Bettinger J, Rougvie A . The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans. Nature. 2000; 403(6772):901-6. DOI: 10.1038/35002607. View

14.

Shedden K, Taylor J, Enkemann S, Tsao M, Yeatman T, Gerald W . Gene expression-based survival prediction in lung adenocarcinoma: a multi-site, blinded validation study. Nat Med. 2008; 14(8):822-7. PMC: 2667337. DOI: 10.1038/nm.1790. View

15.

Suzuki H, Yamagata K, Sugimoto K, Iwamoto T, Kato S, Miyazono K . Modulation of microRNA processing by p53. Nature. 2009; 460(7254):529-33. DOI: 10.1038/nature08199. View

16.

Calin G, Sevignani C, Dumitru C, Hyslop T, Noch E, Yendamuri S . Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers. Proc Natl Acad Sci U S A. 2004; 101(9):2999-3004. PMC: 365734. DOI: 10.1073/pnas.0307323101. View

17.

Miller Y . Pathogenesis of lung cancer: 100 year report. Am J Respir Cell Mol Biol. 2005; 33(3):216-23. PMC: 2715312. DOI: 10.1165/rcmb.2005-0158OE. View

18.

Ruby J, Jan C, Bartel D . Intronic microRNA precursors that bypass Drosha processing. Nature. 2007; 448(7149):83-6. PMC: 2475599. DOI: 10.1038/nature05983. View

19.

Kumar M, Erkeland S, Pester R, Chen C, Ebert M, Sharp P . Suppression of non-small cell lung tumor development by the let-7 microRNA family. Proc Natl Acad Sci U S A. 2008; 105(10):3903-8. PMC: 2268826. DOI: 10.1073/pnas.0712321105. View

20.

Seike M, Goto A, Okano T, Bowman E, Schetter A, Horikawa I . MiR-21 is an EGFR-regulated anti-apoptotic factor in lung cancer in never-smokers. Proc Natl Acad Sci U S A. 2009; 106(29):12085-90. PMC: 2715493. DOI: 10.1073/pnas.0905234106. View