Practical Tips for Surgical Research: Blinding: Who, What, When, Why, How?

Overview

Journal Can J Surg

Specialty General Surgery

Date 2010 Sep 23

PMID 20858381

Citations 148

Authors

Paul J Karanicolas

Forough Farrokhyar

Mohit Bhandari

Affiliations

Soon will be listed here.

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References

McCulloch P, Taylor I, Sasako M, Lovett B, Griffin D . Randomised trials in surgery: problems and possible solutions. BMJ. 2002; 324(7351):1448-51. PMC: 1123389. DOI: 10.1136/bmj.324.7351.1448. View

Schulz K, Grimes D . Blinding in randomised trials: hiding who got what. Lancet. 2002; 359(9307):696-700. DOI: 10.1016/S0140-6736(02)07816-9. View

Noseworthy J, Ebers G, Vandervoort M, Farquhar R, Yetisir E, Roberts R . The impact of blinding on the results of a randomized, placebo-controlled multiple sclerosis clinical trial. Neurology. 1994; 44(1):16-20. DOI: 10.1212/wnl.44.1.16. View

Sackett D . Commentary: Measuring the success of blinding in RCTs: don't, must, can't or needn't?. Int J Epidemiol. 2007; 36(3):664-5. DOI: 10.1093/ije/dym088. View

Lilford R, Braunholtz D, Harris J, Gill T . Trials in surgery. Br J Surg. 2004; 91(1):6-16. DOI: 10.1002/bjs.4418. View

Powell J, Brown L, Forbes J, Fowkes F, Greenhalgh R, Ruckley C . Final 12-year follow-up of surgery versus surveillance in the UK Small Aneurysm Trial. Br J Surg. 2007; 94(6):702-8. DOI: 10.1002/bjs.5778. View

Karanicolas P, Bhandari M, Taromi B, Akl E, Bassler D, Alonso-Coello P . Blinding of outcomes in trials of orthopaedic trauma: an opportunity to enhance the validity of clinical trials. J Bone Joint Surg Am. 2008; 90(5):1026-33. DOI: 10.2106/JBJS.G.00963. View

Devereaux P, Bhandari M, Clarke M, Montori V, Cook D, Yusuf S . Need for expertise based randomised controlled trials. BMJ. 2005; 330(7482):88. PMC: 543877. DOI: 10.1136/bmj.330.7482.88. View

Devereaux P, Manns B, Ghali W, Quan H, Lacchetti C, Montori V . Physician interpretations and textbook definitions of blinding terminology in randomized controlled trials. JAMA. 2001; 285(15):2000-3. DOI: 10.1001/jama.285.15.2000. View

10.

Karanicolas P, Bhandari M, Walter S, Heels-Ansdell D, Guyatt G . Radiographs of hip fractures were digitally altered to mask surgeons to the type of implant without compromising the reliability of quality ratings or making the rating process more difficult. J Clin Epidemiol. 2008; 62(2):214-223.e1. DOI: 10.1016/j.jclinepi.2008.05.006. View

11.

Yang H, Watson D, Lally C, Devitt P, Game P, Jamieson G . Randomized trial of division versus nondivision of the short gastric vessels during laparoscopic Nissen fundoplication: 10-year outcomes. Ann Surg. 2007; 247(1):38-42. DOI: 10.1097/SLA.0b013e31814a693e. View

12.

Juni P, Altman D, Egger M . Systematic reviews in health care: Assessing the quality of controlled clinical trials. BMJ. 2001; 323(7303):42-6. PMC: 1120670. DOI: 10.1136/bmj.323.7303.42. View

13.

Schulz K, Chalmers I, Hayes R, Altman D . Empirical evidence of bias. Dimensions of methodological quality associated with estimates of treatment effects in controlled trials. JAMA. 1995; 273(5):408-12. DOI: 10.1001/jama.273.5.408. View

14.

Macklin R . The ethical problems with sham surgery in clinical research. N Engl J Med. 1999; 341(13):992-6. DOI: 10.1056/NEJM199909233411312. View

15.

Kao L, Aaron B, Dellinger E . Trials and tribulations: current challenges in conducting clinical trials. Arch Surg. 2003; 138(1):59-62. DOI: 10.1001/archsurg.138.1.59. View

16.

Sackett D . Bias in analytic research. J Chronic Dis. 1979; 32(1-2):51-63. DOI: 10.1016/0021-9681(79)90012-2. View

17.

Altman D, Schulz K . Statistics notes: Concealing treatment allocation in randomised trials. BMJ. 2001; 323(7310):446-7. PMC: 1121039. DOI: 10.1136/bmj.323.7310.446. View

18.

Balk E, Bonis P, Moskowitz H, Schmid C, Ioannidis J, Wang C . Correlation of quality measures with estimates of treatment effect in meta-analyses of randomized controlled trials. JAMA. 2002; 287(22):2973-82. DOI: 10.1001/jama.287.22.2973. View

19.

. Doing More Good Than Harm: The Evaluation of Health Care Interventions. Conference proceedings. New York, New York, March 22-25, 1993. Ann N Y Acad Sci. 1993; 703:1-341. View