Solitary Neurofibroma of the Gingiva with Prominent Differentiation of Meissner Bodies: a Case Report

Overview

Journal Diagn Pathol

Publisher Biomed Central

Specialty Pathology

Date 2010 Sep 23

PMID 20858283

Citations 14

Authors

Jun Ohno

Teruaki Iwahashi

Ryuki Ozasa

Kazuhiko Okamura

Kunihisa Taniguchi

Affiliations

Soon will be listed here.

Abstract

Background: Oral neurofibromas are peripheral nerve sheath tumors, similar to schwannomas. Histological variations in oral neurofibromas are relatively uncommon.

Case Presentation: Here, we present a case of unique variation in the observed characteristics of a neurofibroma, with no relation to neurofibromatosis type-1 or von Recklinghausen disease of the skin. The neurofibroma was observed in the right mandibular gingiva of a 32-year-old Japanese woman. Histologically, it differed from conventional neurofibromas in that the tumor was composed of a mixture of fine fibrillary collagen in sheets and/or cords of neoplastic Schwann cells containing numerous clusters of Meissner bodies. Histologically, these bodies were in contact with neoplastic Schwann cells. The Meissner bodies were immunopositive for S-100 protein, neuron-specific enolase, and vimentin, but were negative for calretinin. CD34-positive spindle cells were observed around the Meissner bodies. No recurrence or signs of other tumors have been observed in the patient for 5 years after tumor resection.

Conclusion: To the best of our knowledge, no formal descriptions of sporadic, solitary neurofibromas containing numerous Meissner bodies occurring in the oral cavity are available in literature. We believe that an uncommon proliferation of Meissner bodies, as seen in the present case, may result from aberrant differentiation of neoplastic Schwann cells.

Citing Articles

A case of solitary neurofibroma in the maxillary gingiva.

Komatsu Y, Takeda Y, Kawai T, Sasou S, Takahashi K, Yamada H J Surg Case Rep. 2022; 2022(7):rjac222.

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Plexiform neurofibroma with nevus of ota-rare presentation.

Taneja L, Dokwal S, Prajapat J, Arya V J Oral Maxillofac Pathol. 2021; 25(2):374.

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Solitary Neurofibroma of the Hard Palate: A Case Report and Literature Review.

Taketomi T, Nakamura K, Teratani Y, Matsuo K, Kusukawa J Am J Case Rep. 2021; 22:e929674.

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Oral neural tumors: Clinicopathologic analysis of 157 cases and review of the literature.

Tamiolakis P, Chrysomali E, Sklavounou-Andrikopoulou A, Nikitakis N J Clin Exp Dent. 2019; 11(8):e721-e731.

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Solitary neurofibroma of the floor of the mouth: rare localization at lingual nerve with intraoral excision.

Broly E, Lefevre B, Zachar D, Hafian H BMC Oral Health. 2019; 19(1):197.

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