Prolonged Control of an HIV Type 1 Escape Variant Following Treatment Interruption in an HLA-B*27-positive Patient

Overview

Journal AIDS Res Hum Retroviruses

Publisher Mary Ann Liebert

Specialty Infectious Diseases

Date 2010 Sep 22

PMID 20854198

Citations 6

Authors

Karen A OConnell

Robert K Pelz

Jason B Dinoso

Eric Dunlop

John Paik-Tesch

Thomas M Williams

Joel N Blankson

Affiliations

Soon will be listed here.

Abstract

The HLA-B*27 allele is overrepresented in patients who control HIV-1 replication without antiretroviral therapy. CD8(+) T cell responses that target the immunodominant KK10 epitope in Gag are thought to play a major role in this control, and escape at R264 of KK10 is often associated with dramatic virologic breakthrough. We present a case in which an HLA-B*27-positive chronic progressor transmitted HIV-1 to an HLA-B*27-positive viremic controller who was temporarily on HAART, but who has since controlled viremia for over 4 years. We hypothesized that differences in the KK10 epitope of these patients would affect pathogenesis and viral fitness, but found no correlation between autologous KK10 mutations and disease progression or between the predicted fitness impact of autologous HLA-B*27-associated mutations and the actual fitness of autologous virus. This case of viral transmission between two HLA-B*27-positive individuals provides further evidence that prolonged control of fully pathogenic HIV-1 is possible.

Citing Articles

Viral and Cellular Factors Leading to the Loss of CD4 Homeostasis in HIV-1 Viremic Nonprogressors.

Colomer-Lluch M, Kilpelainen A, Pernas M, Pena R, Ouchi D, Jimenez-Moyano E J Virol. 2021; 96(1):e0149921.

PMID: 34668779 PMC: 8754213. DOI: 10.1128/JVI.01499-21.

CD8 T cells in HIV control, cure and prevention.

Collins D, Gaiha G, Walker B Nat Rev Immunol. 2020; 20(8):471-482.

PMID: 32051540 PMC: 7222980. DOI: 10.1038/s41577-020-0274-9.

Cross-reactive microbial peptides can modulate HIV-specific CD8+ T cell responses.

Pohlmeyer C, Laskey S, Beck S, Xu D, Capoferri A, Garliss C PLoS One. 2018; 13(2):e0192098.

PMID: 29466365 PMC: 5821448. DOI: 10.1371/journal.pone.0192098.

Impaired human immunodeficiency virus type 1 replicative fitness in atypical viremic non-progressor individuals.

Weber J, Gibson R, Sacka L, Strunin D, Hodek J, Weberova J AIDS Res Ther. 2017; 14:15.

PMID: 28331526 PMC: 5359922. DOI: 10.1186/s12981-017-0144-0.

HLA-B*44 is associated with a lower viral set point and slow CD4 decline in a cohort of Chinese homosexual men acutely infected with HIV-1.

Zhang X, Huang X, Xia W, Li W, Zhang T, Wu H Clin Vaccine Immunol. 2013; 20(7):1048-54.

PMID: 23677320 PMC: 3697455. DOI: 10.1128/CVI.00015-13.

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