Cell Wall Anchoring of the 37-kilodalton Oncofetal Antigen by Lactobacillus Plantarum for Mucosal Cancer Vaccine Delivery

Overview

Journal Appl Environ Microbiol

Specialties Environmental Health
Microbiology

Date 2010 Sep 21

PMID 20851975

Citations 35

Authors

Lasse Fredriksen

Geir Mathiesen

Mouldy Sioud

Vincent G H Eijsink

Affiliations

Soon will be listed here.

Abstract

The 37-kDa oncofetal antigen (OFA), a tumor immunogen expressed on all mammalian cancers examined to date, was secreted and anchored to the cell wall of Lactobacillus plantarum using homologous signal peptides and LPxTG anchors. Orally administered L. plantarum expressing anchored OFA induced a specific immune response against OFA in mice.

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