Genetic Alterations in Children and Adolescents with Acute Myeloid Leukaemia

Overview

Journal Clin Transl Oncol

Specialty Oncology

Date 2010 Sep 21

PMID 20851799

Citations 1

Authors

Amparo Verdeguer

Affiliations

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Abstract

Acute Myeloid Leukemia is a clinically and genetically heterogeneous disease, in which cytogenetic aberrations are the most important factors to determine biological behavior and prognosis. More than 20 different chromosomal abnormalities have been identified in a high percentage of children (70-85%) with the novo AML. We reviewed the most frequently found and the impact of these aberrations on prognosis. Differences according to the age of patients and mainly in relation to adult population have been enhanced, although the low incidence of AML in children and the high number of abnormalities make difficult to accurately define the prognosis significance of these aberrations.

Citing Articles

A Multicenter Experience from Lebanon in Childhood and Adolescent Acute Myeloid Leukemia: High rate of Early Death in Childhood Acute Promyelocytic Leukemia.

Farah R, Horkos J, Bustros Y, Farhat H, Abla O Mediterr J Hematol Infect Dis. 2015; 7(1):e2015012.

PMID: 25574371 PMC: 4283923. DOI: 10.4084/MJHID.2015.012.

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