Diffuse Plexiform Neurofibroma of the Back: Report of a Case

Overview

Journal Hawaii Med J

Specialties Biomedical Engineering
General Medicine

Date 2010 Sep 17

PMID 20845284

Citations 10

Authors

Ezella N Washington

Timothy P Placket

Ronald A Gagliano

Jeffery Kavolius

Donald A Person

Affiliations

Soon will be listed here.

Abstract

Neurofibromatosis type 1 is an autosomal dominant disorder affecting the ras proto-oncogene. It is characterized by the overgrowth of nervous tissue and skin discoloration. While it is associated with a variety of phenotypic presentations, it is the plexiform variant that is particular concerning, as it can become extremely disfiguring and has a propensity for malignant degeneration. A case of a Pacific Islander with a large plexiform type 1 neurofibroma is presented. The patient was ultimately treated with surgical resection, negative pressure wound therapy, and split-thickness skin grafting with good results. A review of the literature concerning the diagnosis and treatment of neurofibromatosis is included.

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