Heat Shock Proteins and Drosophila Aging

Overview

Journal Exp Gerontol

Specialty Geriatrics

Date 2010 Sep 16

PMID 20840862

Citations 65

Authors

John Tower

Affiliations

Soon will be listed here.

Abstract

Since their discovery in Drosophila, the heat shock proteins (Hsps) have been shown to regulate both stress resistance and life-span. Aging is characterized by increased oxidative stress and the accumulation of abnormal (malfolded) proteins, and these stresses induce Hsp gene expression through the transcription factor HSF. In addition, a subset of Hsps is induced by oxidative stress through the JNK signaling pathway and the transcription factor Foxo. The Hsps counteract the toxicity of abnormal proteins by facilitating protein refolding and turnover, and through other mechanisms including inhibition of apoptosis. The Hsps are up-regulated in tissue-specific patterns during aging, and their expression correlates with, and sometimes predicts, life span, making them ideal biomarkers of aging. The tools available for experimentally manipulating gene function and assaying healthspan in Drosophila provides an unparalleled opportunity to further study the role of Hsps in aging.

Citing Articles

A statistical mechanics investigation of unfolded protein response across organisms.

Luchetti N, Smith K, Matarrese M, Loppini A, Filippi S, Chiodo L Sci Rep. 2024; 14(1):27658.

PMID: 39532983 PMC: 11557608. DOI: 10.1038/s41598-024-79086-8.

Exposure to the Natural Compound Climacostol Induces Cell Damage and Oxidative Stress in the Fruit Fly .

Catalani E, Brunetti K, Del Quondam S, Bongiorni S, Picchietti S, Fausto A Toxics. 2024; 12(2).

PMID: 38393197 PMC: 10891975. DOI: 10.3390/toxics12020102.

Integrative Analyses of Transcriptomics and Metabolomics in Immune Response of Mats to Infection.

Fei H, Cui J, Zhu S, Xia Y, Xing Y, Gao Y Insects. 2024; 15(2).

PMID: 38392545 PMC: 10889468. DOI: 10.3390/insects15020126.

Impact of Heat Stress on Transposable Element Expression and Derived Small RNAs in Drosophila subobscura.

Bodelon A, Fablet M, Siqueira de Oliveira D, Vieira C, Garcia Guerreiro M Genome Biol Evol. 2023; 15(11).

PMID: 37847062 PMC: 10627563. DOI: 10.1093/gbe/evad189.

What do we mean by "aging"? Questions and perspectives revealed by studies in Drosophila.

Wodrich A, Scott A, Giniger E Mech Ageing Dev. 2023; 213:111839.

PMID: 37354919 PMC: 10330756. DOI: 10.1016/j.mad.2023.111839.

References

Fuda N, Ardehali M, Lis J . Defining mechanisms that regulate RNA polymerase II transcription in vivo. Nature. 2009; 461(7261):186-92. PMC: 2833331. DOI: 10.1038/nature08449. View

Linford N, Pletcher S . Aging: fruit flies break the chain to a longer life. Curr Biol. 2009; 19(19):R895-8. DOI: 10.1016/j.cub.2009.08.050. View

Kenyon C . The genetics of ageing. Nature. 2010; 464(7288):504-12. DOI: 10.1038/nature08980. View

Murphy C, McCarroll S, Bargmann C, Fraser A, Kamath R, Ahringer J . Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans. Nature. 2003; 424(6946):277-83. DOI: 10.1038/nature01789. View

Walerych D, Olszewski M, Gutkowska M, Helwak A, Zylicz M, Zylicz A . Hsp70 molecular chaperones are required to support p53 tumor suppressor activity under stress conditions. Oncogene. 2009; 28(48):4284-94. DOI: 10.1038/onc.2009.281. View

Liao P, Lin H, Yuh C, Yu L, Wang H . The effect of neuronal expression of heat shock proteins 26 and 27 on lifespan, neurodegeneration, and apoptosis in Drosophila. Biochem Biophys Res Commun. 2008; 376(4):637-41. DOI: 10.1016/j.bbrc.2008.08.161. View

Morimoto R, Cuervo A . Protein homeostasis and aging: taking care of proteins from the cradle to the grave. J Gerontol A Biol Sci Med Sci. 2009; 64(2):167-70. PMC: 2655025. DOI: 10.1093/gerona/gln071. View

Hao X, Zhang S, Timakov B, Zhang P . The Hsp27 gene is not required for Drosophila development but its activity is associated with starvation resistance. Cell Stress Chaperones. 2008; 12(4):364-72. PMC: 2134798. DOI: 10.1379/csc-308.1. View

Rollet E, Lavoie J, Landry J, Tanguay R . Expression of Drosophila's 27 kDa heat shock protein into rodent cells confers thermal resistance. Biochem Biophys Res Commun. 1992; 185(1):116-20. DOI: 10.1016/s0006-291x(05)80963-5. View

10.

Marzetti E, Lees H, Wohlgemuth S, Leeuwenburgh C . Sarcopenia of aging: underlying cellular mechanisms and protection by calorie restriction. Biofactors. 2009; 35(1):28-35. PMC: 5992495. DOI: 10.1002/biof.5. View

11.

Carey J, Papadopoulos N, Kouloussis N, Katsoyannos B, Muller H, Wang J . Age-specific and lifetime behavior patterns in Drosophila melanogaster and the Mediterranean fruit fly, Ceratitis capitata. Exp Gerontol. 2005; 41(1):93-7. PMC: 2387245. DOI: 10.1016/j.exger.2005.09.014. View

12.

Bhole D, Allikian M, Tower J . Doxycycline-regulated over-expression of hsp22 has negative effects on stress resistance and life span in adult Drosophila melanogaster. Mech Ageing Dev. 2004; 125(9):651-63. DOI: 10.1016/j.mad.2004.08.010. View

13.

Garesse R, Kaguni L . A Drosophila model of mitochondrial DNA replication: proteins, genes and regulation. IUBMB Life. 2005; 57(8):555-61. DOI: 10.1080/15216540500215572. View

14.

Ghosh S, Feany M . Comparison of pathways controlling toxicity in the eye and brain in Drosophila models of human neurodegenerative diseases. Hum Mol Genet. 2004; 13(18):2011-8. DOI: 10.1093/hmg/ddh214. View

15.

Curran S, Wu X, Riedel C, Ruvkun G . A soma-to-germline transformation in long-lived Caenorhabditis elegans mutants. Nature. 2009; 459(7250):1079-84. PMC: 2716045. DOI: 10.1038/nature08106. View

16.

Zou S, Meadows S, Sharp L, Jan L, Jan Y . Genome-wide study of aging and oxidative stress response in Drosophila melanogaster. Proc Natl Acad Sci U S A. 2000; 97(25):13726-31. PMC: 17643. DOI: 10.1073/pnas.260496697. View

17.

Drummond D, Wilke C . The evolutionary consequences of erroneous protein synthesis. Nat Rev Genet. 2009; 10(10):715-24. PMC: 2764353. DOI: 10.1038/nrg2662. View

18.

Wang M, Bohmann D, Jasper H . JNK signaling confers tolerance to oxidative stress and extends lifespan in Drosophila. Dev Cell. 2003; 5(5):811-6. DOI: 10.1016/s1534-5807(03)00323-x. View

19.

Ren C, Finkel S, Tower J . Conditional inhibition of autophagy genes in adult Drosophila impairs immunity without compromising longevity. Exp Gerontol. 2008; 44(3):228-35. PMC: 2664319. DOI: 10.1016/j.exger.2008.10.002. View

20.

Tatar M, Khazaeli A, Curtsinger J . Chaperoning extended life. Nature. 1997; 390(6655):30. DOI: 10.1038/36237. View