New Insights into Ovarian Function

Overview

Journal Handb Exp Pharmacol

Specialty Pharmacology

Date 2010 Sep 15

PMID 20839083

Citations 13

Authors

JoAnne S Richards

Stephanie A Pangas

Affiliations

Soon will be listed here.

Abstract

Infertility adversely affects many couples worldwide. Conversely, the exponential increase in world population threatens our planet and its resources. Therefore, a greater understanding of the fundamental cellular and molecular events that control the size of the primordial follicle pool and follicular development is of utmost importance to develop improved in vitro fertilization as well as to design novel approaches to regulate fertility. In this review we attempt to highlight some new advances in basic research of the mammalian ovary that have occurred in recent years focusing primarily on mouse models that have contributed to our understanding of ovarian follicle formation, development, and ovulation. We hope that these new insights into ovarian function will trigger more research and translation to clinically relevant problems.

Citing Articles

Identification of FSH-regulated and estrous stage-specific transcriptional networks in mouse ovaries.

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The Impact of the Endocrine and Immunological Function of Adipose Tissue on Reproduction in Women with Obesity.

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Double Negative T Regulatory Cells: An Emerging Paradigm Shift in Reproductive Immune Tolerance?.

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PRMT5 regulates ovarian follicle development by facilitating translation.

Dong F, Chen M, Shen Z, Wu H, Cen C, Cui X Elife. 2021; 10.

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