Effects of Mulberry Leaf Extract Rich in 1-deoxynojirimycin on Blood Lipid Profiles in Humans

Overview

Journal J Clin Biochem Nutr

Specialty Biochemistry

Date 2010 Sep 15

PMID 20838571

Citations 25

Authors

Yoshihiro Kojima

Toshiyuki Kimura

Kiyotaka Nakagawa

Akira Asai

Keiji Hasumi

Shinichi Oikawa

Teruo Miyazawa

Affiliations

Soon will be listed here.

Abstract

Mulberry leaves are rich in 1-deoxynojirimycin (DNJ), an inhibitor of α-glucosidase. We previously showed that DNJ-rich mulberry leaf extract suppressed elevation of postprandial blood glucose in humans. The objective of this study was to evaluate the effects of DNJ-rich mulberry leaf extract on plasma lipid profiles in humans. An open-label, single-group study was conducted in 10 subjects with initial serum triglyceride (TG) level ≥200 mg/dl. Subjects ingested capsules containing DNJ-rich mulberry leaf extract at 12 mg three times daily before meals for 12 weeks. Our findings showed a modest decrease in serum TG level and beneficial changes in the lipoprotein profile following 12-week administration of DNJ-rich mulberry leaf extract. No significant changes in hematological or biochemical parameters were observed during the study period; no adverse events associated with DNJ-rich mulberry leaf extract occurred.

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