Historical Perspective on Mitochondrial Medicine

Overview

Journal Dev Disabil Res Rev

Date 2010 Sep 7

PMID 20818724

Citations 13

Authors

Salvatore DiMauro

Caterina Garone

Affiliations

Soon will be listed here.

Abstract

In this review, we trace the origins and follow the development of mitochondrial medicine from the premolecular era (1962-1988) based on clinical clues, muscle morphology, and biochemistry into the molecular era that started in 1988 and is still advancing at a brisk pace. We have tried to stress conceptual advances, such as endosymbiosis, uniparental inheritance, intergenomic signaling and its defects, and mitochondrial dynamics. We hope that this historical review also provides an update on mitochondrial medicine, although we fully realize that the speed of progress in this area makes any such endeavor akin to writing on water.

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