Plant Homeodomain Fingers Form a Helping Hand for Transcription

Overview

Journal Epigenetics

Specialty Genetics

Date 2010 Sep 7

PMID 20818169

Citations 31

Authors

Klaus Fortschegger

Ramin Shiekhattar

Affiliations

Soon will be listed here.

Abstract

Several recent publications demonstrate a co-activator function for a subgroup of plant homeodomain fingers, which in humans comprises PHF2, PHF8 and KIAA1718. Besides an N-terminal plant homeodomain (PHD) these proteins also harbor an enzymatically active Jumonji-C domain (JmjC). While they have been shown to bind via their PHDs to H3K4me3-bearing nucleosomes at active gene promoters, their JmjC-domains are able to remove mono- and dimethyl-lysine 9 or 27 on histone H3, and monomethyl-lysine 20 on histone H4, chromatin modifications which correlate with transcriptional repression. Such dual histone crosstalk insures the proper removal of repressive histone marks following transcriptional activation by RNA polymerases I and II. Mutations in the PHF8 gene lead to X-linked mental retardation (XLMR) and knockdown of KIAA1718 and PHF8 homologs in zebrafish causes brain defects. Thus, the co-activator function of this new class of chromatin modifying enzymes has important functional roles in neuronal development. To continue with the nomenclature for histone demethylases, we propose the usage of KDM7A, -B and -C for KIAA1718, PHF8 and PHF2 proteins, respectively.

Citing Articles

PHF2-mediated H3K9me balance orchestrates heterochromatin stability and neural progenitor proliferation.

Aguirre S, Pappa S, Serna-Pujol N, Padilla N, Iacobucci S, Nacht A EMBO Rep. 2024; 25(8):3486-3505.

PMID: 38890452 PMC: 11315909. DOI: 10.1038/s44319-024-00178-7.

KDM4B mutations in human cancers.

Bush W, Bosart K, Bouley R, Petreaca R Mutat Res. 2024; 829:111866.

PMID: 38878505 PMC: 11585459. DOI: 10.1016/j.mrfmmm.2024.111866.

PHF2 regulates sarcomeric gene transcription in myogenesis.

Fukushima T, Hasegawa Y, Kuse S, Fujioka T, Nikawa T, Masubuchi S PLoS One. 2024; 19(5):e0301690.

PMID: 38701072 PMC: 11068198. DOI: 10.1371/journal.pone.0301690.

Epigenetic control over the cell-intrinsic immune response antagonizes self-renewal in acute myeloid leukemia.

Felipe Fumero E, Walter C, Frenz J, Seifert F, Alla V, Hennig T Blood. 2024; 143(22):2284-2299.

PMID: 38457355 PMC: 11181352. DOI: 10.1182/blood.2023021640.

Palmitoylation-driven PHF2 ubiquitination remodels lipid metabolism through the SREBP1c axis in hepatocellular carcinoma.

Do-Won Jeong , Park J, Kim K, Kim J, Huh J, Seo J Nat Commun. 2023; 14(1):6370.

PMID: 37828054 PMC: 10570296. DOI: 10.1038/s41467-023-42170-0.

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