Anaemia of Prematurity: Pathophysiology and Treatment

Overview

Journal Blood Rev

Publisher Elsevier

Specialty Hematology

Date 2010 Sep 7

PMID 20817366

Citations 47

Authors

Ronald G Strauss

Affiliations

Soon will be listed here.

Abstract

Most infants with birth weight <1.0 kg are given multiple red blood cell (RBC) transfusions within the first few weeks of life. The anaemia of prematurity is caused by untimely birth occurring before placental iron transport and fetal erythropoiesis are complete, by phlebotomy blood losses taken for laboratory testing, by low plasma levels of erythropoietin due to both diminished production and accelerated catabolism, by rapid body growth and need for commensurate increase in red cell volume/mass, and by disorders causing RBC losses due to bleeding and/or hemolysis. RBC transfusions are the mainstay of therapy with recombinant human erythropoietin largely unused because it fails to substantially diminish RBC transfusion needs--despite exerting substantial erythropoietic effects on neonatal marrow.

Citing Articles

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Case Report: Fetomaternal hemorrhage and its association with pronounced neonatal anemia.

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