Administration of GABA(B) Receptor Positive Allosteric Modulators Inhibit the Expression of Previously Established Methamphetamine-induced Conditioned Place Preference

Overview

Journal Behav Brain Res

Specialties Neurology
Psychology
Social Sciences

Date 2010 Sep 1

PMID 20804788

Citations 17

Authors

Robin M Voigt

Amy A Herrold

Jennifer L Riddle

T Celeste Napier

Affiliations

Soon will be listed here.

Abstract

Little is known about the role of GABA(B) receptors (GABA(B)Rs) in the maintenance of memories associated with using abused substances. We have embarked on a series of studies designed to determine if enhancing the efficacy of GABA-occupied GABA(B)Rs with positive allosteric modulators (PAMs) can negate previously established conditioned place preference (CPP) induced by methamphetamine. In the current study, we evaluated the effects of acute administration of GABA(B)R PAMs, GS39783 and CGP7930. We determined that post-conditioning treatments with these PAMs, administered in the home cage, blocked the subsequent expression of methamphetamine-induced CPP. These data indicate that selectively augmenting GABA-occupied GABA(B)R signaling is sufficient to reduce memory maintenance and/or the salience of contextual cues previously associated with methamphetamine.

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