» Articles » PMID: 20804202

Nitrile-containing Pharmaceuticals: Efficacious Roles of the Nitrile Pharmacophore

Overview
Journal J Med Chem
Specialty Chemistry
Date 2010 Sep 1
PMID 20804202
Citations 212
Authors
Affiliations
Soon will be listed here.
Citing Articles

Mechanistic insights into novel cyano-pyrimidine pendant chalcone derivatives as LSD1 inhibitors by docking, ADMET, MM/GBSA, and molecular dynamics simulation.

Gupta A, Parveen D, Azam F, Shaquiquzzaman M, Akhter M, Jaremko M Biochem Biophys Rep. 2025; 41:101937.

PMID: 40028038 PMC: 11871483. DOI: 10.1016/j.bbrep.2025.101937.


l-Proline catalysed synthesis and studies of novel α-cyano bis(indolyl)chalcones as potential anti-cancer agents.

Malik M, Roy N, Sakkarai Mohamed A, Lotana H, Shah K, Kumar D RSC Adv. 2025; 15(6):4593-4606.

PMID: 39931398 PMC: 11809490. DOI: 10.1039/d4ra06796g.


Dibenzothiophenium Salts: Practical Alternatives to Hypervalent I(III)-Based Reagents.

Alcarazo M Acc Chem Res. 2025; 58(4):635-646.

PMID: 39895033 PMC: 11840934. DOI: 10.1021/acs.accounts.4c00804.


BrCFCN for photocatalytic cyanodifluoromethylation.

Yang X, Lin J, Xiao J Nat Commun. 2025; 16(1):445.

PMID: 39774954 PMC: 11707358. DOI: 10.1038/s41467-024-55797-4.


Hydrogen Bond Blueshifts in Nitrile Vibrational Spectra Are Dictated by Hydrogen Bond Geometry and Dynamics.

Kirsh J, Kozuch J JACS Au. 2024; 4(12):4844-4855.

PMID: 39735926 PMC: 11672138. DOI: 10.1021/jacsau.4c00811.


References
1.
Bose P, Ozer H . Neratinib: an oral, irreversible dual EGFR/HER2 inhibitor for breast and non-small cell lung cancer. Expert Opin Investig Drugs. 2009; 18(11):1735-51. DOI: 10.1517/13543780903305428. View

2.
Oballa R, Truchon J, Bayly C, Chauret N, Day S, Crane S . A generally applicable method for assessing the electrophilicity and reactivity of diverse nitrile-containing compounds. Bioorg Med Chem Lett. 2006; 17(4):998-1002. DOI: 10.1016/j.bmcl.2006.11.044. View

3.
Caponigro F, Casale M, Bryce J . Farnesyl transferase inhibitors in clinical development. Expert Opin Investig Drugs. 2003; 12(6):943-54. DOI: 10.1517/13543784.12.6.943. View

4.
Okamoto K, Matsumoto K, Hille R, Eger B, Pai E, Nishino T . The crystal structure of xanthine oxidoreductase during catalysis: implications for reaction mechanism and enzyme inhibition. Proc Natl Acad Sci U S A. 2004; 101(21):7931-6. PMC: 419534. DOI: 10.1073/pnas.0400973101. View

5.
Horstkotter C, Schepmann D, Blaschke G . Separation and identification of zaleplon metabolites in human urine using capillary electrophoresis with laser-induced fluorescence detection and liquid chromatography-mass spectrometry. J Chromatogr A. 2003; 1014(1-2):71-81. DOI: 10.1016/s0021-9673(03)00564-8. View