Rho-kinase/ROCK: A Key Regulator of the Cytoskeleton and Cell Polarity

Overview

Journal Cytoskeleton (Hoboken)

Specialty Cell Biology

Date 2010 Aug 31

PMID 20803696

Citations 471

Authors

Mutsuki Amano

Masanori Nakayama

Kozo Kaibuchi

Affiliations

Soon will be listed here.

Abstract

Rho-associated kinase (Rho-kinase/ROCK/ROK) is an effector of the small GTPase Rho and belongs to the AGC family of kinases. Rho-kinase has pleiotropic functions including the regulation of cellular contraction, motility, morphology, polarity, cell division, and gene expression. Pharmacological analyses have revealed that Rho-kinase is involved in a wide range of diseases such as vasospasm, pulmonary hypertension, nerve injury, and glaucoma, and is therefore considered to be a potential therapeutic target. This review focuses on the structure, function, and modes of activation and action of Rho-kinase.

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