Exploratory Study on Oxygen Consumption On-kinetics During Treadmill Walking in Women with Systemic Lupus Erythematosus

Overview

Journal Arch Phys Med Rehabil

Specialty Rehabilitation Medicine

Date 2010 Aug 31

PMID 20801259

Citations 8

Authors

Randall E Keyser

Violeta Rus

Jamal A Mikdashi

Barry S Handwerger

Affiliations

Soon will be listed here.

Abstract

Objective: To determine whether oxygen consumption (V o(2)) on-kinetics differed between groups of women with systemic lupus erythematosus (SLE) and sedentary but otherwise healthy controls.

Design: Exploratory case-control study.

Setting: Medical school exercise physiology laboratory.

Participants: Convenience samples of women with SLE (n=12) and sedentary but otherwise healthy controls (n=10).

Intervention: None.

Main Outcome Measures: V o(2) on-kinetics indices including time to steady state, rate constant, mean response time (MRT), transition constant, and oxygen deficit measured during bouts of treadmill walking at intensities of 3 and 5 metabolic equivalents (METs).

Results: Time to steady state and oxygen deficit were increased and rate constant was decreased in the women with SLE compared with controls. At the 5-MET energy demand, the transition constant was lower and MRT was longer in the women with SLE than in controls. For a similar relative energy expenditure that was slightly lower than the anaerobic threshold, the transition constant was higher in controls than in women with SLE.

Conclusion: V o(2) on-kinetics was prolonged in women with SLE. The prolongation was concomitant with an increase in oxygen deficit and may underlie performance fatigability in women with SLE.

Citing Articles

Carbon Dioxide Expiration and Performance Fatigability Following Aerobic Exercise Training: A Longitudinal, Observational, Pilot Study.

Wooten L, Neville B, Guccione A, Chin L, Keyser R Cardiopulm Phys Ther J. 2023; 32(1):3-10.

PMID: 37614414 PMC: 10445408. DOI: 10.1097/cpt.0000000000000162.

Role of Respiratory Buffering in the Relationship Between Recovery and Performance Fatigability Following Aerobic Exercise Training: A Longitudinal, Observational, Pilot Study.

Wooten L, Neville B, Guccione A, Chin L, Keyser R Cardiopulm Phys Ther J. 2023; 32(1):11-19.

PMID: 37583789 PMC: 10425857. DOI: 10.1097/cpt.0000000000000151.

Cardiorespiratory Insufficiency and Performance Fatigability in Women with Systemic Lupus Erythematosus.

Wooten L, Hasni S, Mikdashi J, Keyser R Cardiopulm Phys Ther J. 2023; 34(1):51-60.

PMID: 36742346 PMC: 9897569. DOI: 10.1097/cpt.0000000000000210.

Moreira-Reis A, Mate-Munoz J, Hernandez-Lougedo J, Garcia-Fernandez P, Heredia-Elvar J, Pleguezuelos E Biology (Basel). 2022; 11(11).

PMID: 36358347 PMC: 9687828. DOI: 10.3390/biology11111646.

The association of breathing pattern with exercise tolerance and perceived fatigue in women with systemic lupus erythematosus: an exploratory case-control study.

Aldhahi M, Wooten L, Hasni S, Mikdashi J, Keyser R Rheumatol Int. 2021; 42(11):2003-2011.

PMID: 34727196 DOI: 10.1007/s00296-021-05005-z.

References

Kinker J, Haffor A, Stephan M, Clanton T . Kinetics of CO uptake and diffusing capacity in transition from rest to steady-state exercise. J Appl Physiol (1985). 1992; 72(5):1764-72. DOI: 10.1152/jappl.1992.72.5.1764. View

Engelen M, Porszasz J, Riley M, Wasserman K, Maehara K, Barstow T . Effects of hypoxic hypoxia on O2 uptake and heart rate kinetics during heavy exercise. J Appl Physiol (1985). 1996; 81(6):2500-8. DOI: 10.1152/jappl.1996.81.6.2500. View

Cerretelli P, AMBROSOLI G, Fumagalli M . Anaerobic recovery in man. Eur J Appl Physiol Occup Physiol. 1975; 34(3):141-8. DOI: 10.1007/BF00999926. View

Norton W . Endothelial inclusions in active lesions of systemic lupus erythematosus. J Lab Clin Med. 1969; 74(3):369-79. View

Zoladz J, Gladden L, Hogan M, Nieckarz Z, Grassi B . Progressive recruitment of muscle fibers is not necessary for the slow component of VO2 kinetics. J Appl Physiol (1985). 2008; 105(2):575-80. DOI: 10.1152/japplphysiol.01129.2007. View

Adams N, Bestall J, Jones P, Lasserson T, Griffiths B, Cates C . Inhaled fluticasone at different doses for chronic asthma in adults and children. Cochrane Database Syst Rev. 2005; (3):CD003534. DOI: 10.1002/14651858.CD003534.pub2. View

DeLorey D, Kowalchuk J, Heenan A, duManoir G, Paterson D . Prior exercise speeds pulmonary O2 uptake kinetics by increases in both local muscle O2 availability and O2 utilization. J Appl Physiol (1985). 2007; 103(3):771-8. DOI: 10.1152/japplphysiol.01061.2006. View

Lebrun C, Petit M, McKenzie D, Taunton J, Prior J . Decreased maximal aerobic capacity with use of a triphasic oral contraceptive in highly active women: a randomised controlled trial. Br J Sports Med. 2003; 37(4):315-20. PMC: 1724664. DOI: 10.1136/bjsm.37.4.315. View

Gurd B, Peters S, Heigenhauser G, LeBlanc P, Doherty T, Paterson D . Prior heavy exercise elevates pyruvate dehydrogenase activity and speeds O2 uptake kinetics during subsequent moderate-intensity exercise in healthy young adults. J Physiol. 2006; 577(Pt 3):985-96. PMC: 1890376. DOI: 10.1113/jphysiol.2006.112706. View

10.

Barstow T, Jones A, Nguyen P, Casaburi R . Influence of muscle fibre type and fitness on the oxygen uptake/power output slope during incremental exercise in humans. Exp Physiol. 2000; 85(1):109-16. View

11.

Norton W, Hurd E, Lewis D, ZIFF M . Evidence of microvascular injury in scleroderma and systemic lupus erythematosus: quantitative study of the microvascular bed. J Lab Clin Med. 1968; 71(6):919-33. View

12.

Tench C, Bentley D, Vleck V, McCurdie I, White P, DCruz D . Aerobic fitness, fatigue, and physical disability in systemic lupus erythematosus. J Rheumatol. 2002; 29(3):474-81. View

13.

Farrell P, Wilmore J, Coyle E, Billing J, Costill D . Plasma lactate accumulation and distance running performance. Med Sci Sports. 1979; 11(4):338-44. View

14.

Caputo F, Mello M, Denadai B . Oxygen uptake kinetics and time to exhaustion in cycling and running: a comparison between trained and untrained subjects. Arch Physiol Biochem. 2005; 111(5):461-6. DOI: 10.3109/13813450312331342337. View

15.

Hughson R, Xing H, Butler G, Northey D . Effect of hypoxia on VO2 kinetics during pseudorandom binary sequence exercise. Aviat Space Environ Med. 1990; 61(3):236-9. View

16.

Carvalho M, Sato E, Tebexreni A, Heidecher R, Schenkman S, Barros Neto T . Effects of supervised cardiovascular training program on exercise tolerance, aerobic capacity, and quality of life in patients with systemic lupus erythematosus. Arthritis Rheum. 2005; 53(6):838-44. DOI: 10.1002/art.21605. View

17.

Krupp L, Larocca N, Muir J, Steinberg A . A study of fatigue in systemic lupus erythematosus. J Rheumatol. 1990; 17(11):1450-2. View

18.

Palange P, Galassetti P, Mannix E, Farber M, MANFREDI F, Serra P . Oxygen effect on O2 deficit and VO2 kinetics during exercise in obstructive pulmonary disease. J Appl Physiol (1985). 1995; 78(6):2228-34. DOI: 10.1152/jappl.1995.78.6.2228. View

19.

Arena R, Humphrey R, Peberdy M, Madigan M . Comparison of oxygen uptake on-kinetic calculations in heart failure. Med Sci Sports Exerc. 2002; 34(10):1563-9. DOI: 10.1097/00005768-200210000-00006. View

20.

BRUCE R, Kusumi F, Hosmer D . Maximal oxygen intake and nomographic assessment of functional aerobic impairment in cardiovascular disease. Am Heart J. 1973; 85(4):546-62. DOI: 10.1016/0002-8703(73)90502-4. View