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Isolation and Characterization of Karlotoxin 1, a New Amphipathic Toxin from Karlodinium Veneficum

Overview
Journal Tetrahedron Lett
Publisher Elsevier
Specialty Chemistry
Date 2010 Aug 28
PMID 20798789
Citations 33
Authors
Ryan M Van Wagoner
Jonathan R Deeds
Masayuki Satake
Anthony A Ribeiro
Allen R Place
Jeffrey L C Wright
Affiliations
Soon will be listed here.
Abstract

The karlotoxins (KmTxs) are a family of compounds produced by the dinoflagellate Karlodinium veneficum that cause membrane permeabilization. The structure of KmTx 1, determined using extensive 2D NMR spectroscopy, is very similar to the amphidinols and related compounds, though KmTx 1 features unique structural modifications of the conserved core region. The structure of KmTx 1 differs from that reported for KmTx 2, the only other reported karlotoxin to date, in lacking chlorination at its terminal alkene and possessing a hydrophobic arm that is two carbons longer.

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