Association of Blood Lactate with Type 2 Diabetes: the Atherosclerosis Risk in Communities Carotid MRI Study

Overview

Journal Int J Epidemiol

Specialty Public Health

Date 2010 Aug 28

PMID 20797988

Citations 102

Authors

Stephen O Crawford

Ron C Hoogeveen

Frederick L Brancati

Brad C Astor

Christie M Ballantyne

Maria Ines Schmidt

Jeffery Hunter Young

Affiliations

Soon will be listed here.

Abstract

Background: Accumulating evidence implicates insufficient oxidative capacity in the development of type 2 diabetes. This notion has not been well tested in large, population-based studies.

Methods: To test this hypothesis, we assessed the cross-sectional association of plasma lactate, an indicator of the gap between oxidative capacity and energy expenditure, with type 2 diabetes in 1709 older adults not taking metformin, who were participants in the Atherosclerosis Risk in Communities (ARIC) Carotid MRI Study.

Results: The prevalence of type 2 diabetes rose across lactate quartiles (11, 14, 20 and 30%; P for trend <0.0001). Following adjustment for demographic factors, physical activity, body mass index and waist circumference, the relative odds of type 2 diabetes across lactate quartiles were 0.98 [95% confidence interval (CI) 0.59-1.64], 1.64 (95% CI 1.03-2.64) and 2.23 (95% CI 1.38-3.59), respectively. Furthermore, lactate was associated with higher fasting glucose among non-diabetic adults.

Conclusions: Plasma lactate was strongly associated with type 2 diabetes in older adults. Plasma lactate deserves greater attention in studies of oxidative capacity and diabetes risk.

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