Infection of Human Gastrointestinal Cells by HIV-1

Overview

Journal AIDS Res Hum Retroviruses

Publisher Mary Ann Liebert

Specialty Infectious Diseases

Date 1990 Dec 1

PMID 2078418

Citations 18

Authors

M P Moyer

R I Huot

A Ramirez Jr

S JOE

M S Meltzer

H E Gendelman

Affiliations

Soon will be listed here.

Abstract

Human immunodeficiency virus (HIV-1) infected and replicated in primary cultures of normal human ileal and colonic epithelial cells. Monocyte-tropic strains (ADA, 24, and 36) were better able to replicate in the gastrointestinal (GI) cells than the T-cell-tropic HIV strain HTLV-IIIB. In some cultures, virus replication persisted through several months. Intestinal epithelium may be an initial target and reservoir for HIV and a vector for virus dissemination and transmission.

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Virus infection of polarized epithelial cells.

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