Characterization of Atrophic Changes in the Cerebral Cortex Using Fractal Dimensional Analysis

Overview

Journal Brain Imaging Behav

Publisher Springer

Specialties Neurology
Psychology
Radiology
Social Sciences

Date 2011 Sep 28

PMID 20740072

Citations 43

Authors

Richard D King

Anuh T George

Tina Jeon

Linda S Hynan

Teddy S Youn

David N Kennedy

Bradford Dickerson

Affiliations

Soon will be listed here.

Abstract

The purpose of this project is to apply a modified fractal analysis technique to high-resolution T1 weighted magnetic resonance images in order to quantify the alterations in the shape of the cerebral cortex that occur in patients with Alzheimer's disease. Images were selected from the Alzheimer's Disease Neuroimaging Initiative database (Control N=15, Mild-Moderate AD N=15). The images were segmented using a semi-automated analysis program. Four coronal and three axial profiles of the cerebral cortical ribbon were created. The fractal dimensions (D(f)) of the cortical ribbons were then computed using a box-counting algorithm. The mean D(f) of the cortical ribbons from AD patients were lower than age-matched controls on six of seven profiles. The fractal measure has regional variability which reflects local differences in brain structure. Fractal dimension is complementary to volumetric measures and may assist in identifying disease state or disease progression.

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