Periodicity and Evoked Responses in Motor Cortex

Overview

Journal J Neurosci

Specialty Neurology

Date 2010 Aug 27

PMID 20739573

Citations 28

Authors

Jacob Reimer

Nicholas G Hatsopoulos

Affiliations

Soon will be listed here.

Abstract

Spiking in primary motor cortex (MI) exhibits a characteristic beta frequency periodicity, but the functional relevance of this rhythmic firing is controversial. We simultaneously recorded multiple single units and local field potentials in MI in two monkeys (Macaca mulatta) during continuous, self-paced movements to serially presented targets. We find that the appearance of each new target evokes precisely timed spiking in MI at a characteristic latency but that the exact timing of this response varies depending on its relationship to the phase of the ongoing beta range oscillation. As a result of this interaction between evoked spiking and endogenous beta periodicity, we find that the amount of information about target location encoded in the spiking of MI neurons is not simply a function of elapsed time but depends also on oscillatory phase. Our results suggest that periodicity may be an important feature of the early stages of sensorimotor processing in the cortical motor system.

Citing Articles

Executive function elevated by long term high-intensity physical activity and the regulation role of beta-band activity in human frontal region.

Wang J, Zhao X, Bi Y, Jiang S, Sun Y, Lang J Cogn Neurodyn. 2023; 17(6):1463-1472.

PMID: 37974584 PMC: 10640436. DOI: 10.1007/s11571-022-09905-z.

Done in 65 ms: Express Visuomotor Responses in Upper Limb Muscles in Rhesus Macaques.

Cecala A, Kozak R, Pruszynski J, Corneil B eNeuro. 2023; 10(8).

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Dynamic structure of motor cortical neuron coactivity carries behaviorally relevant information.

Sundiang M, Hatsopoulos N, MacLean J Netw Neurosci. 2023; 7(2):661-678.

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Revisiting the "Paradox of Stereotaxic Surgery": Insights Into Basal Ganglia-Thalamic Interactions.

Magnusson J, Leventhal D Front Syst Neurosci. 2021; 15:725876.

PMID: 34512279 PMC: 8429495. DOI: 10.3389/fnsys.2021.725876.

A specific phase of transcranial alternating current stimulation at the β frequency boosts repetitive paired-pulse TMS-induced plasticity.

Nakazono H, Ogata K, Takeda A, Yamada E, Oka S, Tobimatsu S Sci Rep. 2021; 11(1):13179.

PMID: 34162993 PMC: 8222330. DOI: 10.1038/s41598-021-92768-x.

References

Schoffelen J, Oostenveld R, Fries P . Neuronal coherence as a mechanism of effective corticospinal interaction. Science. 2005; 308(5718):111-3. DOI: 10.1126/science.1107027. View

Montemurro M, Rasch M, Murayama Y, Logothetis N, Panzeri S . Phase-of-firing coding of natural visual stimuli in primary visual cortex. Curr Biol. 2008; 18(5):375-80. DOI: 10.1016/j.cub.2008.02.023. View

Scott S . Apparatus for measuring and perturbing shoulder and elbow joint positions and torques during reaching. J Neurosci Methods. 1999; 89(2):119-27. DOI: 10.1016/s0165-0270(99)00053-9. View

Pfurtscheller G . Event-related synchronization (ERS): an electrophysiological correlate of cortical areas at rest. Electroencephalogr Clin Neurophysiol. 1992; 83(1):62-9. DOI: 10.1016/0013-4694(92)90133-3. View

Baker S . Oscillatory interactions between sensorimotor cortex and the periphery. Curr Opin Neurobiol. 2008; 17(6):649-55. PMC: 2428102. DOI: 10.1016/j.conb.2008.01.007. View

Vargas-Irwin C, Donoghue J . Automated spike sorting using density grid contour clustering and subtractive waveform decomposition. J Neurosci Methods. 2007; 164(1):1-18. PMC: 2104515. DOI: 10.1016/j.jneumeth.2007.03.025. View

Murthy V, Fetz E . Coherent 25- to 35-Hz oscillations in the sensorimotor cortex of awake behaving monkeys. Proc Natl Acad Sci U S A. 1992; 89(12):5670-4. PMC: 49354. DOI: 10.1073/pnas.89.12.5670. View

Churchland M, Yu B, Cunningham J, Sugrue L, Cohen M, Corrado G . Stimulus onset quenches neural variability: a widespread cortical phenomenon. Nat Neurosci. 2010; 13(3):369-78. PMC: 2828350. DOI: 10.1038/nn.2501. View

Lakatos P, Chen C, OConnell M, Mills A, Schroeder C . Neuronal oscillations and multisensory interaction in primary auditory cortex. Neuron. 2007; 53(2):279-92. PMC: 3717319. DOI: 10.1016/j.neuron.2006.12.011. View

10.

Rubino D, Robbins K, Hatsopoulos N . Propagating waves mediate information transfer in the motor cortex. Nat Neurosci. 2006; 9(12):1549-57. DOI: 10.1038/nn1802. View

11.

Womelsdorf T, Schoffelen J, Oostenveld R, Singer W, Desimone R, Engel A . Modulation of neuronal interactions through neuronal synchronization. Science. 2007; 316(5831):1609-12. DOI: 10.1126/science.1139597. View

12.

Schaefer A, Angelo K, Spors H, Margrie T . Neuronal oscillations enhance stimulus discrimination by ensuring action potential precision. PLoS Biol. 2006; 4(6):e163. PMC: 1459879. DOI: 10.1371/journal.pbio.0040163. View

13.

Fries P, Neuenschwander S, Engel A, Goebel R, Singer W . Rapid feature selective neuronal synchronization through correlated latency shifting. Nat Neurosci. 2001; 4(2):194-200. DOI: 10.1038/84032. View

14.

Cardin J, Carlen M, Meletis K, Knoblich U, Zhang F, Deisseroth K . Driving fast-spiking cells induces gamma rhythm and controls sensory responses. Nature. 2009; 459(7247):663-7. PMC: 3655711. DOI: 10.1038/nature08002. View

15.

Riddle C, Baker S . Manipulation of peripheral neural feedback loops alters human corticomuscular coherence. J Physiol. 2005; 566(Pt 2):625-39. PMC: 1464768. DOI: 10.1113/jphysiol.2005.089607. View

16.

Salinas E, Sejnowski T . Correlated neuronal activity and the flow of neural information. Nat Rev Neurosci. 2001; 2(8):539-50. PMC: 2868968. DOI: 10.1038/35086012. View

17.

MacLeod K, Backer A, Laurent G . Who reads temporal information contained across synchronized and oscillatory spike trains?. Nature. 1998; 395(6703):693-8. DOI: 10.1038/27201. View

18.

Makeig S, Westerfield M, Jung T, Enghoff S, Townsend J, Courchesne E . Dynamic brain sources of visual evoked responses. Science. 2002; 295(5555):690-4. DOI: 10.1126/science.1066168. View

19.

Fries P . A mechanism for cognitive dynamics: neuronal communication through neuronal coherence. Trends Cogn Sci. 2005; 9(10):474-80. DOI: 10.1016/j.tics.2005.08.011. View

20.

Lamarre Y, Busby L, Spidalieri G . Fast ballistic arm movements triggered by visual, auditory, and somesthetic stimuli in the monkey. I. Activity of precentral cortical neurons. J Neurophysiol. 1983; 50(6):1343-58. DOI: 10.1152/jn.1983.50.6.1343. View