Immune Therapeutic Targeting of Glioma Cancer Stem Cells

Overview

Journal Target Oncol

Specialty Oncology

Date 2010 Aug 26

PMID 20737294

Citations 18

Authors

Mustafa Aziz Hatiboglu

Jun Wei

Adam Sauh Gee Wu

Amy B Heimberger

Affiliations

Soon will be listed here.

Abstract

Glioblastoma multiforme (GBM) is a lethal cancer that responds poorly to radiotherapy and chemotherapy. Glioma cancer stem cells (gCSCs) have been shown to recapitulate the characteristic features of GBM and to mediate chemotherapy and radiation resistance. Immunotherapeutic targeting of this cell population holds therapeutic promise but must be considered in the context of the immunosuppressive properties mediated by the gCSC. Recent findings have indicated that this goal will be challenging because the gCSC can suppress both the innate and adaptive immune systems by a variety of gCSC-secreted products and cell-membrane interactions. In this review article, we will attempt to reconcile the disparate research findings regarding the potential of immune targeting of the gCSC and propose several novel solutions.

Citing Articles

Current approaches in glioblastoma multiforme immunotherapy.

Aghajani M, Jalilzadeh N, Aghebati-Maleki A, Yari A, Tabnak P, Mardi A Clin Transl Oncol. 2024; 26(7):1584-1612.

PMID: 38512448 DOI: 10.1007/s12094-024-03395-7.

Multifaceted WNT Signaling at the Crossroads Between Epithelial-Mesenchymal Transition and Autophagy in Glioblastoma.

Coelho B, Fernandes C, Boccacino J, Souza M, Melo-Escobar M, Alves R Front Oncol. 2020; 10:597743.

PMID: 33312955 PMC: 7706883. DOI: 10.3389/fonc.2020.597743.

Extracellular Vesicle lncRNA Metastasis-Associated Lung Adenocarcinoma Transcript 1 Released From Glioma Stem Cells Modulates the Inflammatory Response of Microglia After Lipopolysaccharide Stimulation Through Regulating miR-129-5p/High Mobility....

Yang J, Sun G, Hu Y, Yang J, Shi Y, Liu H Front Immunol. 2020; 10:3161.

PMID: 32117213 PMC: 7020807. DOI: 10.3389/fimmu.2019.03161.

Glioblastoma Stem Cells and Comparison of Isolation Methods.

Dundar T, Hatiboglu M, Ergul Z, Seyithanoglu M, Sozen E, Tuzgen S J Clin Med Res. 2019; 11(6):415-421.

PMID: 31143308 PMC: 6522234. DOI: 10.14740/jocmr3781.

The role of cancer stem cells in the modulation of anti-tumor immune responses.

Maccalli C, Rasul K, Elawad M, Ferrone S Semin Cancer Biol. 2018; 53:189-200.

PMID: 30261276 PMC: 8668198. DOI: 10.1016/j.semcancer.2018.09.006.

References

Singh S, Clarke I, Terasaki M, Bonn V, Hawkins C, Squire J . Identification of a cancer stem cell in human brain tumors. Cancer Res. 2003; 63(18):5821-8. View

Ausiello C, Palma C, Maleci A, Spagnoli G, Amici C, Antonelli G . Cell mediated cytotoxicity and cytokine production in peripheral blood mononuclear cells of glioma patients. Eur J Cancer. 1991; 27(5):646-50. DOI: 10.1016/0277-5379(91)90235-6. View

Kostianovsky A, Maier L, Anderson R, Bruce J, Anderson D . Astrocytic regulation of human monocytic/microglial activation. J Immunol. 2008; 181(8):5425-32. DOI: 10.4049/jimmunol.181.8.5425. View

Cobbs C, Soroceanu L, Denham S, Zhang W, Britt W, Pieper R . Human cytomegalovirus induces cellular tyrosine kinase signaling and promotes glioma cell invasiveness. J Neurooncol. 2007; 85(3):271-80. DOI: 10.1007/s11060-007-9423-2. View

Hussain S, Yang D, Suki D, Grimm E, Heimberger A . Innate immune functions of microglia isolated from human glioma patients. J Transl Med. 2006; 4:15. PMC: 1501057. DOI: 10.1186/1479-5876-4-15. View

Bao S, Wu Q, McLendon R, Hao Y, Shi Q, Hjelmeland A . Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature. 2006; 444(7120):756-60. DOI: 10.1038/nature05236. View

Morford L, ELLIOTT L, Carlson S, Brooks W, Roszman T . T cell receptor-mediated signaling is defective in T cells obtained from patients with primary intracranial tumors. J Immunol. 1997; 159(9):4415-25. View

Zhang L, Alizadeh D, Van Handel M, Kortylewski M, Yu H, Badie B . Stat3 inhibition activates tumor macrophages and abrogates glioma growth in mice. Glia. 2009; 57(13):1458-67. DOI: 10.1002/glia.20863. View

El Andaloussi A, Lesniak M . CD4+ CD25+ FoxP3+ T-cell infiltration and heme oxygenase-1 expression correlate with tumor grade in human gliomas. J Neurooncol. 2007; 83(2):145-52. DOI: 10.1007/s11060-006-9314-y. View

10.

Mancino A, Lawrence T . Nuclear factor-kappaB and tumor-associated macrophages. Clin Cancer Res. 2010; 16(3):784-9. PMC: 6485421. DOI: 10.1158/1078-0432.CCR-09-1015. View

11.

Quintana E, Shackleton M, Sabel M, Fullen D, Johnson T, Morrison S . Efficient tumour formation by single human melanoma cells. Nature. 2008; 456(7222):593-8. PMC: 2597380. DOI: 10.1038/nature07567. View

12.

Hedvat M, Huszar D, Herrmann A, Gozgit J, Schroeder A, Sheehy A . The JAK2 inhibitor AZD1480 potently blocks Stat3 signaling and oncogenesis in solid tumors. Cancer Cell. 2009; 16(6):487-97. PMC: 2812011. DOI: 10.1016/j.ccr.2009.10.015. View

13.

Yu J, Liu G, Ying H, Yong W, Black K, Wheeler C . Vaccination with tumor lysate-pulsed dendritic cells elicits antigen-specific, cytotoxic T-cells in patients with malignant glioma. Cancer Res. 2004; 64(14):4973-9. DOI: 10.1158/0008-5472.CAN-03-3505. View

14.

Wu A, Wei J, Kong L, Wang Y, Priebe W, Qiao W . Glioma cancer stem cells induce immunosuppressive macrophages/microglia. Neuro Oncol. 2010; 12(11):1113-25. PMC: 3098021. DOI: 10.1093/neuonc/noq082. View

15.

Boniface K, Bak-Jensen K, Li Y, Blumenschein W, McGeachy M, McClanahan T . Prostaglandin E2 regulates Th17 cell differentiation and function through cyclic AMP and EP2/EP4 receptor signaling. J Exp Med. 2009; 206(3):535-48. PMC: 2699124. DOI: 10.1084/jem.20082293. View

16.

Jordan C, Guzman M, Noble M . Cancer stem cells. N Engl J Med. 2006; 355(12):1253-61. DOI: 10.1056/NEJMra061808. View

17.

Butowski N, Chang S, Junck L, DeAngelis L, Abrey L, Fink K . A phase II clinical trial of poly-ICLC with radiation for adult patients with newly diagnosed supratentorial glioblastoma: a North American Brain Tumor Consortium (NABTC01-05). J Neurooncol. 2008; 91(2):175-82. PMC: 4779120. DOI: 10.1007/s11060-008-9693-3. View

18.

Lee J, Kotliarova S, Kotliarov Y, Li A, Su Q, Donin N . Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines. Cancer Cell. 2006; 9(5):391-403. DOI: 10.1016/j.ccr.2006.03.030. View

19.

Wei J, Barr J, Kong L, Wang Y, Wu A, Sharma A . Glioblastoma cancer-initiating cells inhibit T-cell proliferation and effector responses by the signal transducers and activators of transcription 3 pathway. Mol Cancer Ther. 2010; 9(1):67-78. PMC: 2939737. DOI: 10.1158/1535-7163.MCT-09-0734. View

20.

Fecci P, Mitchell D, Whitesides J, Xie W, Friedman A, Archer G . Increased regulatory T-cell fraction amidst a diminished CD4 compartment explains cellular immune defects in patients with malignant glioma. Cancer Res. 2006; 66(6):3294-302. DOI: 10.1158/0008-5472.CAN-05-3773. View