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Labeling and Imaging of Stem Cells - Promises and Concerns

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Specialty Hematology
Date 2010 Aug 26
PMID 20737050
Citations 5
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Abstract

For experimental and clinical applications of stem cells cell labeling and tracking is interesting to evaluate cell distribution and homing. Tracking of cells after transplantation can be performed for monitoring the delivery and faith of the graft. Furthermore, imaging techniques are part of the evaluation of the functional effects of cellular therapy in the organism of the host. Therefore, systematic investigations on the development and clinical evaluation of imaging techniques and their possible biological impact on stem cells is an emerging topic of today's applied stem cell research. This article refers to different labeling techniques of stem cells highlighting their promises for clinical use and discussing their possible risks.

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References
1.
Reimer P, Weissleder R, Lee A, Wittenberg J, Brady T . Receptor imaging: application to MR imaging of liver cancer. Radiology. 1990; 177(3):729-34. DOI: 10.1148/radiology.177.3.2243978. View

2.
de Vries I, Krooshoop D, Scharenborg N, Lesterhuis W, Diepstra J, van Muijen G . Effective migration of antigen-pulsed dendritic cells to lymph nodes in melanoma patients is determined by their maturation state. Cancer Res. 2003; 63(1):12-7. View

3.
Terrovitis J, Kwok K, Lautamaki R, Engles J, Barth A, Kizana E . Ectopic expression of the sodium-iodide symporter enables imaging of transplanted cardiac stem cells in vivo by single-photon emission computed tomography or positron emission tomography. J Am Coll Cardiol. 2008; 52(20):1652-60. PMC: 4980098. DOI: 10.1016/j.jacc.2008.06.051. View

4.
Sonoda S, Tachibana K, Uchino E, Okubo A, Yamamoto M, Sakoda K . Gene transfer to corneal epithelium and keratocytes mediated by ultrasound with microbubbles. Invest Ophthalmol Vis Sci. 2006; 47(2):558-64. DOI: 10.1167/iovs.05-0889. View

5.
Yeh T, Zhang W, Ildstad S, Ho C . In vivo dynamic MRI tracking of rat T-cells labeled with superparamagnetic iron-oxide particles. Magn Reson Med. 1995; 33(2):200-8. DOI: 10.1002/mrm.1910330209. View