A Challenge for the Future: Aging and HIV Infection

Overview

Journal Immunol Res

Specialty Allergy & Immunology

Date 2010 Aug 25

PMID 20734158

Citations 7

Authors

Tammy M Rickabaugh

Beth D Jamieson

Affiliations

Soon will be listed here.

Abstract

Older individuals (≥50 years of age) are increasingly becoming a new at-risk group for HIV-1 infection and, together with those surviving longer due to the introduction of anti-retroviral therapy (ART), it is predicted that more than half of all HIV-1-infected individuals in the United States will be greater than 50 years of age in the year 2015. Older individuals diagnosed with HIV-1 are prone to faster disease progression and reduced T-cell reconstitution despite successful virologic control with anti-retroviral therapy (ART). There is also growing evidence that the T-cell compartment in HIV-1(+) adults displays an aged phenotype, and HIV-1-infected individuals are increasingly diagnosed with clinical conditions more commonly seen in older uninfected persons. As aging in the absence of HIV infection is associated with alterations in T-cell function and immunosenescence, the combined impact of both HIV-1 infection and aging may provide an explanation for poorer clinical outcomes observed in older HIV-1-infected individuals. Thus, the development of novel therapeutics to stimulate immune function and delay immunosenescence is critical and would be beneficial to both the elderly and HIV-1-infected individuals.

Citing Articles

Adults Aged ≥50 Years Reached by the Centers for Disease Control and Prevention's HIV Testing Programs in the United States and US Dependent Areas, 2019.

Marano-Lee M, Williams W, Huang T, Uhl G Public Health Rep. 2022; 138(4):625-632.

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Harnessing CD8 T Cells Under HIV Antiretroviral Therapy.

Warren J, Clutton G, Goonetilleke N Front Immunol. 2019; 10:291.

PMID: 30863403 PMC: 6400228. DOI: 10.3389/fimmu.2019.00291.

Immunosenescence and hurdles in the clinical management of older HIV-patients.

Ripa M, Chiappetta S, Tambussi G Virulence. 2017; 8(5):508-528.

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An assessment of the levels of perceived social support among older adults living with HIV and AIDS in Dublin.

Okonkwo N, Larkan F, Galligan M Springerplus. 2016; 5(1):726.

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CD4:CD8 ratio as a frontier marker for clinical outcome, immune dysfunction and viral reservoir size in virologically suppressed HIV-positive patients.

Lu W, Mehraj V, Vyboh K, Cao W, Li T, Routy J J Int AIDS Soc. 2015; 18:20052.

PMID: 26130226 PMC: 4486418. DOI: 10.7448/IAS.18.1.20052.

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