A Multiparameter Approach to Monitor Disease Activity in Collagen-induced Arthritis

Overview

Journal Arthritis Res Ther

Publisher Biomed Central

Specialty Rheumatology

Date 2010 Aug 25

PMID 20731827

Citations 38

Authors

Sylvie Seeuws

Peggy Jacques

Jens van Praet

Michael Drennan

Julie Coudenys

Tine Decruy

Ellen Deschepper

Lien Lepescheux

Philippe Pujuguet

Line Oste

Nick Vandeghinste

Reginald Brys

Gust Verbruggen

Dirk Elewaut

Affiliations

Soon will be listed here.

Abstract

Introduction: Disease severity in collagen-induced arthritis (CIA) is commonly assessed by clinical scoring of paw swelling and histological examination of joints. Although this is an accurate approach, it is also labour-intensive and the application of less invasive and less time-consuming methods is of great interest. However, it is still unclear which of these methods represents the most discriminating measure of disease activity.

Methods: We undertook a comparative analysis in which different measurements of inflammation and tissue damage in CIA were studied on an individual mouse level. We compared the current gold standard methods - clinical scoring and histological examination - with alternative methods based on scoring of X-ray or micro-computed tomography (CT) images and investigated the significance of systemically expressed proteins, involved in CIA pathogenesis, that have potential as biomarkers.

Results: Linear regression analysis revealed a marked association of serum matrix metalloproteinase (MMP)-3 levels with all features of CIA including inflammation, cartilage destruction and bone erosions. This association was improved by combined detection of MMP-3 and anti-collagen IgG2a antibody concentrations. In addition, combined analysis of both X-ray and micro-CT images was found to be predictive for cartilage and bone damage. Most remarkably, validation analysis using an independent data set proved that variations in disease severity, induced by different therapies, could be accurately represented by predicted values based on the proposed parameters.

Conclusions: Our analyses revealed that clinical scoring, combined with serum MMP-3, anti-collagen IgG2a measurement and scoring of X-ray and micro-CT images, yields a comprehensive insight into the different aspects of disease activity in CIA.

Citing Articles

Targeting TRPC channels for control of arthritis-induced bone erosion.

Ray S, McCall J, Tian J, Jeon J, Douglas A, Tyler K Sci Adv. 2025; 11(3):eabm9843.

PMID: 39813349 PMC: 11734723. DOI: 10.1126/sciadv.abm9843.

Sinulariolide Suppresses Inflammation of Fibroblast-Like Synoviocytes in Rheumatoid Arthritis and Mitigates Collagen-Induced Arthritis Symptoms in Mice.

Tsai S, Cheng Y, Chao Y, Yang D J Inflamm Res. 2024; 17:8299-8311.

PMID: 39525321 PMC: 11550694. DOI: 10.2147/JIR.S476847.

Chinese traditional medicine DZGP beneficially affects gut microbiome, serum metabolites and recovery from rheumatoid arthritis through mediating NF-κB signaling pathway.

Zhao L, Zheng K, Wan X, Xiao Q, Yuan L, Wu C Heliyon. 2024; 10(13):e33706.

PMID: 39071566 PMC: 11283109. DOI: 10.1016/j.heliyon.2024.e33706.

Bench to Bedside: Modelling Inflammatory Arthritis.

Chidomere C, Wahid M, Kemble S, Chadwick C, Thomas R, Hardy R Discov Immunol. 2024; 2(1):kyac010.

PMID: 38567064 PMC: 10917191. DOI: 10.1093/discim/kyac010.

Regulation of rheumatoid arthritis microenvironment a self-healing injectable hydrogel for improved inflammation elimination and bone repair.

Geng W, Zhao J, Tao B, Yang Y, Duan Q, Gao P Bioact Mater. 2024; 36:287-300.

PMID: 38496033 PMC: 10940865. DOI: 10.1016/j.bioactmat.2024.03.002.

References

Williams R . Collagen-induced arthritis in mice. Methods Mol Med. 2007; 136:191-9. DOI: 10.1007/978-1-59745-402-5_14. View

Boini S, Guillemin F . Radiographic scoring methods as outcome measures in rheumatoid arthritis: properties and advantages. Ann Rheum Dis. 2001; 60(9):817-27. PMC: 1753828. View

Young-Min S, Cawston T, Marshall N, Coady D, Christgau S, Saxne T . Biomarkers predict radiographic progression in early rheumatoid arthritis and perform well compared with traditional markers. Arthritis Rheum. 2007; 56(10):3236-47. DOI: 10.1002/art.22923. View

Hasty K, Reife R, Kang A, Stuart J . The role of stromelysin in the cartilage destruction that accompanies inflammatory arthritis. Arthritis Rheum. 1990; 33(3):388-97. DOI: 10.1002/art.1780330312. View

Larsson E, Erlandsson Harris H, Larsson A, Mansson B, Saxne T, Klareskog L . Corticosteroid treatment of experimental arthritis retards cartilage destruction as determined by histology and serum COMP. Rheumatology (Oxford). 2004; 43(4):428-34. DOI: 10.1093/rheumatology/keh073. View

Kim W, Yoo W, Park W, Kang Y, Kim S, Park J . IgG antibodies to type II collagen reflect inflammatory activity in patients with rheumatoid arthritis. J Rheumatol. 2000; 27(3):575-81. View

Nishida S, Tsurukami H, Sakai A, Sakata T, Ikeda S, Tanaka M . Stage-dependent changes in trabecular bone turnover and osteogenic capacity of marrow cells during development of type II collagen-induced arthritis in mice. Bone. 2002; 30(6):872-9. DOI: 10.1016/s8756-3282(02)00725-1. View

Cheung N, Dawes P, Poulton K, Ollier W, Taylor D, Mattey D . High serum levels of pro-matrix metalloproteinase-3 are associated with greater radiographic damage and the presence of the shared epitope in patients with rheumatoid arthritis. J Rheumatol. 2000; 27(4):882-7. View

Marinova-Mutafchieva L, Williams R, Mason L, Mauri C, Feldmann M, Maini R . Dynamics of proinflammatory cytokine expression in the joints of mice with collagen-induced arthritis (CIA). Clin Exp Immunol. 1997; 107(3):507-12. DOI: 10.1046/j.1365-2249.1997.2901181.x. View

10.

Yoshihara Y, Obata K, Fujimoto N, Yamashita K, Hayakawa T, Shimmei M . Increased levels of stromelysin-1 and tissue inhibitor of metalloproteinases-1 in sera from patients with rheumatoid arthritis. Arthritis Rheum. 1995; 38(7):969-75. DOI: 10.1002/art.1780380713. View

11.

Brand D, Kang A, Rosloniec E . Immunopathogenesis of collagen arthritis. Springer Semin Immunopathol. 2003; 25(1):3-18. DOI: 10.1007/s00281-003-0127-1. View

12.

Larsen A . How to apply Larsen score in evaluating radiographs of rheumatoid arthritis in long-term studies. J Rheumatol. 1995; 22(10):1974-5. View

13.

Cho Y, Cho M, Min S, Kim H . Type II collagen autoimmunity in a mouse model of human rheumatoid arthritis. Autoimmun Rev. 2007; 7(1):65-70. DOI: 10.1016/j.autrev.2007.08.001. View

14.

Noguchi M, Kimoto A, Sasamata M, Miyata K . Micro-CT imaging analysis for the effect of celecoxib, a cyclooxygenase-2 inhibitor, on inflammatory bone destruction in adjuvant arthritis rats. J Bone Miner Metab. 2008; 26(5):461-8. DOI: 10.1007/s00774-008-0855-3. View

15.

So A, Chamot A, Peclat V, Gerster J . Serum MMP-3 in rheumatoid arthritis: correlation with systemic inflammation but not with erosive status. Rheumatology (Oxford). 1999; 38(5):407-10. DOI: 10.1093/rheumatology/38.5.407. View

16.

Watson W, Townes A . Genetic susceptibility to murine collagen II autoimmune arthritis. Proposed relationship to the IgG2 autoantibody subclass response, complement C5, major histocompatibility complex (MHC) and non-MHC loci. J Exp Med. 1985; 162(6):1878-91. PMC: 2187982. DOI: 10.1084/jem.162.6.1878. View

17.

Manicourt D, Fujimoto N, Obata K, Thonar E . Levels of circulating collagenase, stromelysin-1, and tissue inhibitor of matrix metalloproteinases 1 in patients with rheumatoid arthritis. Relationship to serum levels of antigenic keratan sulfate and systemic parameters of inflammation. Arthritis Rheum. 1995; 38(8):1031-9. DOI: 10.1002/art.1780380803. View

18.

Coppieters K, Dreier T, Silence K, de Haard H, Lauwereys M, Casteels P . Formatted anti-tumor necrosis factor alpha VHH proteins derived from camelids show superior potency and targeting to inflamed joints in a murine model of collagen-induced arthritis. Arthritis Rheum. 2006; 54(6):1856-66. DOI: 10.1002/art.21827. View

19.

Gravallese E . Bone destruction in arthritis. Ann Rheum Dis. 2002; 61 Suppl 2:ii84-6. PMC: 1766721. DOI: 10.1136/ard.61.suppl_2.ii84. View

20.

Tchetverikov I, Ronday H, van El B, Kiers G, Verzijl N, TeKoppele J . MMP profile in paired serum and synovial fluid samples of patients with rheumatoid arthritis. Ann Rheum Dis. 2004; 63(7):881-3. PMC: 1755080. DOI: 10.1136/ard.2003.013243. View