An Overview of Commonly Used Radiographic Scoring Methods in Rheumatoid Arthritis Clinical Trials

Overview

Journal Clin Rheumatol

Publisher Springer

Specialty Rheumatology

Date 2010 Aug 24

PMID 20730549

Citations 8

Authors

Vinod Ravindran

Satish Rachapalli

Affiliations

Soon will be listed here.

Abstract

Despite the advent of magnetic resonance imaging and musculoskeletal ultrasound, the plain radiographs of the hands and feet remain an important tool for a practising rheumatologist both in clinical and research settings. This review focuses on providing a historical overview of commonly used methods of scoring radiographs in rheumatoid arthritis and discusses technical issues related to radiographic scoring, limitations and advantages of radiographs, and current recommendations regarding reporting radiographic data in clinical trials.

Citing Articles

An autoantibody profile identified by human genome-wide protein arrays in rheumatoid arthritis.

Liu X, Zhang X, Kang Y, Huang F, Liu S, Guo Y MedComm (2020). 2024; 5(8):e679.

PMID: 39132510 PMC: 11317183. DOI: 10.1002/mco2.679.

Assessment of Disease Activity, Structural Damage, and Function in Rheumatoid Arthritis.

Ishizaki J, Hasegawa H Methods Mol Biol. 2024; 2766:325-333.

PMID: 38270892 DOI: 10.1007/978-1-0716-3682-4_33.

Fully automatic software for detecting radiographic joint space narrowing progression in rheumatoid arthritis: phantom study and comparison with visual assessment.

Okino T, Ou Y, Ikebe M, Tamura K, Sutherland K, Fukae J Jpn J Radiol. 2022; 41(5):510-520.

PMID: 36538163 DOI: 10.1007/s11604-022-01373-z.

Prognostic Factors for Radiographic Progression in Patients with Seronegative Rheumatoid Arthritis.

Park E, Jeong W, Kim J J Pers Med. 2021; 11(3).

PMID: 33807932 PMC: 8001159. DOI: 10.3390/jpm11030184.

Cartilage oligomeric matrix protein (COMP) in rheumatoid arthritis and its correlation with sonographic knee cartilage thickness and disease activity.

Sakthiswary R, Rajalingam S, Hussein H, Sridharan R, Asrul A Clin Rheumatol. 2017; 36(12):2683-2688.

PMID: 28889184 DOI: 10.1007/s10067-017-3817-0.

References

Nance Jr E, KAYE J, Callahan L, Carroll F, WINFIELD A, Earthman W . Observer variation in quantitative assessment of rheumatoid arthritis. Part I. Scoring erosions and joint space narrowing. Invest Radiol. 1986; 21(12):922-7. DOI: 10.1097/00004424-198612000-00007. View

Scott D, Laasonen L, Priolo F, Houssien D, Bacarini L, Cerase A . The radiological assessment of rheumatoid arthritis. Clin Exp Rheumatol. 1997; 15 Suppl 17:S53-61. View

KAYE J, Nance Jr E, Callahan L, Carroll F, WINFIELD A, Earthman W . Observer variation in quantitative assessment of rheumatoid arthritis Part II. A simplified scoring system. Invest Radiol. 1987; 22(1):41-6. DOI: 10.1097/00004424-198701000-00006. View

Landewe R, van der Heijde D . Presentation and analysis of radiographic data in clinical trials and observational studies. Ann Rheum Dis. 2005; 64 Suppl 4:iv48-51. PMC: 1766912. DOI: 10.1136/ard.2005.042572. View

Hulsmans H, Jacobs J, van der Heijde D, van Albada-Kuipers G, Schenk Y, Bijlsma J . The course of radiologic damage during the first six years of rheumatoid arthritis. Arthritis Rheum. 2000; 43(9):1927-40. DOI: 10.1002/1529-0131(200009)43:9<1927::AID-ANR3>3.0.CO;2-B. View

Bridges Jr S, Causey Z, Burgos P, Huynh B, Hughes L, Danila M . Radiographic severity of rheumatoid arthritis in African Americans: results from a multicenter observational study. Arthritis Care Res (Hoboken). 2010; 62(5):624-31. PMC: 3052790. DOI: 10.1002/acr.20040. View

Boini S, Guillemin F . Radiographic scoring methods as outcome measures in rheumatoid arthritis: properties and advantages. Ann Rheum Dis. 2001; 60(9):817-27. PMC: 1753828. View

Paimela L . The radiographic criterion in the 1987 revised criteria for rheumatoid arthritis. Reassessment in a prospective study of early disease. Arthritis Rheum. 1992; 35(3):255-8. DOI: 10.1002/art.1780350303. View

Drossaers-Bakker K, de Buck M, van Zeben D, Zwinderman A, Breedveld F, Hazes J . Long-term course and outcome of functional capacity in rheumatoid arthritis: the effect of disease activity and radiologic damage over time. Arthritis Rheum. 1999; 42(9):1854-60. DOI: 10.1002/1529-0131(199909)42:9<1854::AID-ANR9>3.0.CO;2-F. View

10.

Solymossy C, Dixey J, Utley M, Gallivan S, Young A, Cox N . Larsen scoring of digitized X-ray images. Rheumatology (Oxford). 1999; 38(11):1127-9. DOI: 10.1093/rheumatology/38.11.1127. View

11.

Kassimos D, Creamer P . The hand X-ray in rheumatology. Hosp Med. 2004; 65(1):13-7. DOI: 10.12968/hosp.2004.65.1.2412. View

12.

Sharp J . Speculations on why early treatment of rheumatoid arthritis is uniquely effective. J Rheumatol. 2008; 35(11):2090-3. DOI: 10.3899/jrheum.080671. View

13.

Rau R, Wassenberg S, Herborn G, Stucki G, Gebler A . A new method of scoring radiographic change in rheumatoid arthritis. J Rheumatol. 1998; 25(11):2094-107. View

14.

van der Heijde D . Radiographic progression in rheumatoid arthritis: does it reflect outcome? Does it reflect treatment?. Ann Rheum Dis. 2002; 60 Suppl 3:iii47-50. PMC: 1766669. DOI: 10.1136/ard.60.90003.iii47. View

15.

van der Heijde D, van Riel P, Nuver-Zwart I, Gribnau F, vad de Putte L . Effects of hydroxychloroquine and sulphasalazine on progression of joint damage in rheumatoid arthritis. Lancet. 1989; 1(8646):1036-8. DOI: 10.1016/s0140-6736(89)92442-2. View

16.

Sharp J, Lidsky M, Collins L, Moreland J . Methods of scoring the progression of radiologic changes in rheumatoid arthritis. Correlation of radiologic, clinical and laboratory abnormalities. Arthritis Rheum. 1971; 14(6):706-20. DOI: 10.1002/art.1780140605. View

17.

Sharp J, Young D, Bluhm G, Brook A, Brower A, Corbett M . How many joints in the hands and wrists should be included in a score of radiologic abnormalities used to assess rheumatoid arthritis?. Arthritis Rheum. 1985; 28(12):1326-35. DOI: 10.1002/art.1780281203. View

18.

Ravindran V, Seah M, Elias D, Choy E, Scott D, Gordon P . Clinical and radiological features of rheumatoid arthritis in British black Africans. Clin Rheumatol. 2007; 27(1):97-100. DOI: 10.1007/s10067-007-0735-6. View

19.

Genant H, Jiang Y, Peterfy C, Lu Y, Redei J, Countryman P . Assessment of rheumatoid arthritis using a modified scoring method on digitized and original radiographs. Arthritis Rheum. 1998; 41(9):1583-90. DOI: 10.1002/1529-0131(199809)41:9<1583::AID-ART8>3.0.CO;2-H. View

20.

van der Heijde D, van Leeuwen M, van Riel P, Koster A, van t Hof M, van Rijswijk M . Biannual radiographic assessments of hands and feet in a three-year prospective followup of patients with early rheumatoid arthritis. Arthritis Rheum. 1992; 35(1):26-34. DOI: 10.1002/art.1780350105. View