Inhibition of the Activity of Both Domains of Lysostaphin Through Peptidoglycan Modification by the Lysostaphin Immunity Protein

Overview

Journal Appl Environ Microbiol

Specialties Environmental Health
Microbiology

Date 2010 Aug 24

PMID 20729317

Citations 9

Authors

Shaw R Gargis

Harry E Heath

Paul A Leblanc

Linda Dekker

Robin S Simmonds

Gary L Sloan

Affiliations

Soon will be listed here.

Abstract

Resistance to lysostaphin, a staphylolytic glycylglycine endopeptidase, is due to a FemABX-like immunity protein that inserts serines in place of some glycines in peptidoglycan cross bridges. These modifications inhibit both binding of the recombinant cell wall targeting domain and catalysis by the recombinant catalytic domain of lysostaphin.

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