Gastrointestinal Stromal Tumors (GISTs): an Updated Experience

Overview

Journal Dig Dis Sci

Specialty Gastroenterology

Date 2010 Aug 21

PMID 20725786

Citations 13

Authors

Anastasios Machairas

Eva Karamitopoulou

Dimitrios Tsapralis

Theodore Karatzas

Nickolas Machairas

Evangelos P Misiakos

Affiliations

Soon will be listed here.

Abstract

Background: Gastrointestinal stromal tumors (GISTs) are relatively common mesenchymal tumors of the digestive tract characterized by c-KIT mutations. This is a comprehensive review of the current data of the literature on the various aspects of the diagnosis and treatment of these tumors.

Methods: The stomach is the most commonly involved site for these tumors in the digestive tract. Computed tomography and endoscopy can usually establish the diagnosis. The study of certain specific immunohistochemical markers may contribute to better characterization of these tumors.

Results: Surgical resection of GISTs has been the most effective therapy. In addition, targeted therapy with tyrosine kinase inhibitors may reduce the development of recurrence or decrease the disease progression in patients with metastatic disease.

Conclusions: The introduction of tyrosine kinase inhibitors has resulted in significant improvement in the overall prognosis of these patients. Furthermore, preoperative imatinib can decrease tumor volume and is associated with complete surgical resection in locally advanced primary GISTs.

Citing Articles

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Gastrointestinal stromal tumor in the fourth portion of the duodenum does not express the CD117: A case report.

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Primary gastrointestinal stromal tumor of the left hepatic lobe: a case report and a review of the literature.

Piachas A, Tooulias A, Tsoulfas G J Surg Case Rep. 2022; 2021(12):rjab572.

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Association Between the Nutritional Risk and the Survival Rate in Newly Diagnosed GIST Patients.

Ding P, Guo H, Yang P, Sun C, Tian Y, Liu Y Front Nutr. 2021; 8:743475.

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Life-threatening haematochezia in a man with two gastrointestinal stromal tumours.

Moin K, Alneyadi M, Shantour S, Alao D BMJ Case Rep. 2021; 14(6).

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