The Role of Airborne Proteins in Atopic Dermatitis

Overview

Journal J Clin Aesthet Dermatol

Date 2010 Aug 21

PMID 20725535

Citations 7

Authors

Sarah Grim Hostetler

Benjamin Kaffenberger

Todd Hostetler

Matthew J Zirwas

Affiliations

Soon will be listed here.

Abstract

Atopic dermatitis is a common, chronic skin condition. A subpopulation of patients may have cutaneous exposure to common airborne proteins exacerbating their disease through direct proteolytic activity, direct activation of proteinase-activated receptor-2 itch receptors, and immunoglobulin E binding. The most common airborne proteins significant in atopic dermatitis include house dust mites, cockroach, pet dander, and multiple pollens. The literature on atopy patch testing, skin-prick testing, and specific IgE is mixed, with greater support for the use of atopy patch test. Patients with airborne proteins contributing to their disease typically have lesions predominately on air-exposed skin surfaces including the face, neck, and arms; a history of exacerbations after exposure to airborne proteins; severe disease resistant to conventional therapies; and concurrent asthma. Treatment strategies include airborne protein avoidance, removal of airborne proteins from the skin, and barrier repair. Further research is needed to establish the benefit of allergen-specific immunotherapy.

Citing Articles

Allergens in Atopic Dermatitis.

Zhang J, Li G, Guo Q, Yang Y, Yang J, Feng X Clin Rev Allergy Immunol. 2025; 68(1):11.

PMID: 39924626 DOI: 10.1007/s12016-025-09024-7.

Oral Administration of Expressing Mite and Cockroach Major Allergens Alleviates Progression of Atopic March in a Mouse Model.

Lee M, Chen Y, Chiang C, Wu C, Li M, Wang N Allergy Asthma Immunol Res. 2024; 16(5):520-533.

PMID: 39363770 PMC: 11450443. DOI: 10.4168/aair.2024.16.5.520.

Therapeutic Potential and Mechanisms of Mesenchymal Stem Cell and Mesenchymal Stem Cell-Derived Extracellular Vesicles in Atopic Dermatitis.

He K, Zang J, Ren T, Feng S, Liu M, Zhang X J Inflamm Res. 2024; 17:5783-5800.

PMID: 39224661 PMC: 11368146. DOI: 10.2147/JIR.S479444.

Canine amniotic membrane-derived mesenchymal stem cells ameliorate atopic dermatitis through regeneration and immunomodulation.

Kim M, Kong D, Han M, Roh K, Koo H, Lee S Vet Res Commun. 2023; 47(4):2055-2070.

PMID: 37421548 DOI: 10.1007/s11259-023-10155-5.

Sublingual immunotherapy in mite-sensitized patients with atopic dermatitis: a randomized controlled study.

Yu N, Luo H, Liang D, Lu N Postepy Dermatol Alergol. 2021; 38(2):69-74.

PMID: 34408569 PMC: 8362773. DOI: 10.5114/ada.2021.104281.

References

Deleuran M, Ellingsen A, Paludan K, Schou C, Thestrup-Pedersen K . Purified Der p1 and p2 patch tests in patients with atopic dermatitis: evidence for both allergenicity and proteolytic irritancy. Acta Derm Venereol. 1998; 78(4):241-3. DOI: 10.1080/000155598441783. View

Kato T, Takai T, Fujimura T, Matsuoka H, Ogawa T, Murayama K . Mite serine protease activates protease-activated receptor-2 and induces cytokine release in human keratinocytes. Allergy. 2009; 64(9):1366-74. DOI: 10.1111/j.1398-9995.2009.02023.x. View

Schmidt P, Darsow U, Ring J, Kapp A, Werfel T . Atopy patch test reactions are associated with T lymphocyte-mediated allergen-specific immune responses in atopic dermatitis. Clin Exp Allergy. 1999; 29(4):513-21. DOI: 10.1046/j.1365-2222.1999.00510.x. View

Koopman L, van Strien R, Kerkhof M, Wijga A, Smit H, de Jongste J . Placebo-controlled trial of house dust mite-impermeable mattress covers: effect on symptoms in early childhood. Am J Respir Crit Care Med. 2002; 166(3):307-13. DOI: 10.1164/rccm.2106026. View

Pajno G, Peroni D, Barberio G, Pietrobelli A, Boner A . Predictive features for persistence of atopic dermatitis in children. Pediatr Allergy Immunol. 2003; 14(4):292-5. DOI: 10.1034/j.1399-3038.2003.00060.x. View

Tsitoura S, Nestoridou K, Botis P, Karmaus W, Botezan C, Bojarskas J . Randomized trial to prevent sensitization to mite allergens in toddlers and preschoolers by allergen reduction and education: one-year results. Arch Pediatr Adolesc Med. 2002; 156(10):1021-7. DOI: 10.1001/archpedi.156.10.1021. View

van Strien R, Koopman L, Kerkhof M, Oldenwening M, de Jongste J, Gerritsen J . Mattress encasings and mite allergen levels in the Prevention and Incidence of Asthma and Mite Allergy study. Clin Exp Allergy. 2003; 33(4):490-5. DOI: 10.1046/j.1365-2222.2003.01626.x. View

Mancini A, Kaulback K, Chamlin S . The socioeconomic impact of atopic dermatitis in the United States: a systematic review. Pediatr Dermatol. 2008; 25(1):1-6. DOI: 10.1111/j.1525-1470.2007.00572.x. View

Holm L, Bengtsson A, van Hage-Hamsten M, OHMAN S, Scheynius A . Effectiveness of occlusive bedding in the treatment of atopic dermatitis--a placebo-controlled trial of 12 months' duration. Allergy. 2001; 56(2):152-8. DOI: 10.1034/j.1398-9995.2001.056002152.x. View

10.

Teplitsky V, Mumcuoglu K, Babai I, Dalal I, Cohen R, Tanay A . House dust mites on skin, clothes, and bedding of atopic dermatitis patients. Int J Dermatol. 2008; 47(8):790-5. DOI: 10.1111/j.1365-4632.2008.03657.x. View

11.

Hon K, Leung T, Ching G, Chow C, Luk V, Ko W . Patterns of food and aeroallergen sensitization in childhood eczema. Acta Paediatr. 2008; 97(12):1734-7. DOI: 10.1111/j.1651-2227.2008.01034.x. View

12.

Hon K, Leung T, Lam M, Wong K, Chow C, Fok T . Which aeroallergens are associated with eczema severity?. Clin Exp Dermatol. 2007; 32(4):401-4. DOI: 10.1111/j.1365-2230.2007.02420.x. View

13.

Gutgesell C, Heise S, Seubert S, Seubert A, Domhof S, Brunner E . Double-blind placebo-controlled house dust mite control measures in adult patients with atopic dermatitis. Br J Dermatol. 2001; 145(1):70-4. DOI: 10.1046/j.1365-2133.2001.04283.x. View

14.

Huang J, Chen C, Kuo M, Hsieh K . Exposure to a high concentration of mite allergen in early infancy is a risk factor for developing atopic dermatitis: a 3-year follow-up study. Pediatr Allergy Immunol. 2001; 12(1):11-6. DOI: 10.1034/j.1399-3038.2001.012001011.x. View

15.

Kubota Y, Imayama S, Hori Y . Reduction of environmental mites improved atopic dermatitis patients with positive mite-patch tests. J Dermatol. 1992; 19(3):177-80. DOI: 10.1111/j.1346-8138.1992.tb03202.x. View

16.

Casimir G, Duchateau J, Gossart B, Cuvelier P, Vandaele F, Vis H . Atopic dermatitis: role of food and house dust mite allergens. Pediatrics. 1993; 92(2):252-6. View

17.

Mochizuki H, Muramatsu R, Tadaki H, Mizuno T, Arakawa H, Morikawa A . Effects of skin care with shower therapy on children with atopic dermatitis in elementary schools. Pediatr Dermatol. 2009; 26(2):223-5. DOI: 10.1111/j.1525-1470.2009.00887.x. View

18.

Kameyoshi Y, Tanaka T, Mochizuki M, Koro O, Mihara S, Hiragun T . [Taking showers at school is beneficial for children with severer atopic dermatitis]. Arerugi. 2008; 57(2):130-7. View

19.

Werfel T . The role of leukocytes, keratinocytes, and allergen-specific IgE in the development of atopic dermatitis. J Invest Dermatol. 2009; 129(8):1878-91. DOI: 10.1038/jid.2009.71. View

20.

Darsow U, Vieluf D, Ring J . The atopy patch test: an increased rate of reactivity in patients who have an air-exposed pattern of atopic eczema. Br J Dermatol. 1996; 135(2):182-6. View