Lagochilascaris Minor: Susceptibility and Resistance to Experimental Infection in Mice Is Independent of H-2 Haplotype and Correlates with the Immune Response in Immunized Animals

Overview

Journal J Parasitol Res

Publisher Wiley

Specialty Parasitology

Date 2010 Aug 20

PMID 20721343

Citations 2

Authors

Monica Spadafora-Ferreira

Luciana Caetano Fernandes

Irmtraut Araci Hoffman Pfrimer

Cassia Regina Pichiteli

Denise Vilarinho Tambourgi

Ruy de Souza Lino-Junior

Mara Silvia Carvalhaes

Affiliations

Soon will be listed here.

Abstract

Recently, we demonstrated that C57BL/6 mice are more susceptible to experimental lagochilascariosis than BALB/c mice. To investigate the pattern of infection and the role of the genetic background on susceptibility to infection, we studied experimental lagochilascariosis in H-2(a) identical B10.A and A/J mice. Infected B10.A mice had a lower survival ratio and more severe lesions in the lungs than did A/J mice. Splenocytes of A/J mice immunized with the crude extract of the parasite showed increased proliferation and produced a higher level of interleukin 10 and interferon-gamma in the presence of CE or concanavalin A when compared to B10.A mice. This suggests that resistance of A/J mice may be due to less severe lesions in lungs and other organs and a better immune response to parasite antigens. This paper provides evidence that major histocompatibility complex haplotype does not influence the survival to experimental infection with L. minor.

Citing Articles

Analysis of Spleen Cells in Susceptible and Resistant Mice with Experimental Lagochilascariosis.

Lara P, Prudente M, Dias N, Tambourgi D, Lino-Junior R, Spadafora-Ferreira M ISRN Parasitol. 2016; 2013:180652.

PMID: 27335846 PMC: 4890894. DOI: 10.5402/2013/180652.

A Case of Lagochilascariasis in Suriname with the Involvement of the ENT System and the Skull Base.

Douma J, Akrum R, Joe R, Chan M, Codrington J, Vreden S Am J Trop Med Hyg. 2016; 95(1):88-91.

PMID: 27139450 PMC: 4944716. DOI: 10.4269/ajtmh.15-0792.

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