Effects of Smoking Cessation on Body Composition in Postmenopausal Women

Overview

Journal J Womens Health (Larchmt)

Specialty Gynecology & Obstetrics

Date 2010 Aug 20

PMID 20718625

Citations 16

Authors

Alison Kleppinger

Mark D Litt

Anne M Kenny

Cheryl A Oncken

Affiliations

Soon will be listed here.

Abstract

Background: Smoking cessation is associated with weight gain, but the effects of smoking cessation on measures of body composition (BC) have not been adequately evaluated. The purpose of this study is to examine the effects of 16 months of cigarette abstinence on areas of BC measured by dual-energy x-ray absorptiometry (DXA).

Methods: One hundred fifty-two postmenopausal women participated in a smoking cessation study using the nicotine patch. Secondary analyses were conducted on data from 119 subjects (age 56 +/- 7 years, range 41-78 years) who had had DXA scans at baseline and 16 months later. Participants were classified either as quitters (self-reported cigarette abstinence confirmed with exhaled carbon monoxide [co] <or=8 ppm at 3 and 16 months after quit date) or as continued smokers. BC was assessed using a General Electric Lunar DXA IQ machine. Four areas of BC (kg) were measured: whole body weight, fat mass, muscle mass, and functional skeletal muscle mass in arms and legs (ASM/ht(2)). Multivariate analysis of covariance (MANCOVA) assessed changes in BC in quitters vs. continued smokers between baseline and 16 months of follow-up. Increases in BC measures were evaluated as a function of increased calorie intake or change in physical activity, using linear regression.

Results: Quitters significantly increased body weight (p < 0.001), fat mass (p < 0.001), muscle mass (p = 0.04), and functional muscle mass (p = 0.004) over time, when baseline BC measures and other confounding factors were controlled. Regression analysis indicated change in BC could not be accounted for by calorie intake or physical activity.

Conclusions: Smoking cessation may be associated with increased fat and muscle mass in postmenopausal women. The novel finding of an increase in functional muscle mass suggests that smoking cessation could increase functional capacity. Further studies need to replicate these findings and examine mechanisms of these effects.

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References

Chiolero A, Faeh D, Paccaud F, Cornuz J . Consequences of smoking for body weight, body fat distribution, and insulin resistance. Am J Clin Nutr. 2008; 87(4):801-9. DOI: 10.1093/ajcn/87.4.801. View

Ferrara C, Kumar M, Nicklas B, McCrone S, Goldberg A . Weight gain and adipose tissue metabolism after smoking cessation in women. Int J Obes Relat Metab Disord. 2001; 25(9):1322-6. DOI: 10.1038/sj.ijo.0801716. View

Williamson D, Madans J, Anda R, Kleinman J, Giovino G, Byers T . Smoking cessation and severity of weight gain in a national cohort. N Engl J Med. 1991; 324(11):739-45. DOI: 10.1056/NEJM199103143241106. View

French S, Jeffery R, Pirie P, McBride C . Do weight concerns hinder smoking cessation efforts?. Addict Behav. 1992; 17(3):219-26. DOI: 10.1016/0306-4603(92)90027-s. View

Petersen A, Magkos F, Atherton P, Selby A, Smith K, Rennie M . Smoking impairs muscle protein synthesis and increases the expression of myostatin and MAFbx in muscle. Am J Physiol Endocrinol Metab. 2007; 293(3):E843-8. DOI: 10.1152/ajpendo.00301.2007. View

Baumgartner R, Koehler K, Gallagher D, Romero L, Heymsfield S, Ross R . Epidemiology of sarcopenia among the elderly in New Mexico. Am J Epidemiol. 1998; 147(8):755-63. DOI: 10.1093/oxfordjournals.aje.a009520. View

French S, Hennrikus D, Jeffery R . Smoking status, dietary intake, and physical activity in a sample of working adults. Health Psychol. 1996; 15(6):448-54. DOI: 10.1037//0278-6133.15.6.448. View

Saarni S, Silventoinen K, Rissanen A, Sarlio-Lahteenkorva S, Kaprio J . Recurrent dieting and smoking among Finnish men and women. Obesity (Silver Spring). 2007; 15(7):1851-9. DOI: 10.1038/oby.2007.219. View

Canoy D, Wareham N, Luben R, Welch A, Bingham S, Day N . Cigarette smoking and fat distribution in 21,828 British men and women: a population-based study. Obes Res. 2005; 13(8):1466-75. DOI: 10.1038/oby.2005.177. View

10.

Lee J, Auyeung T, Kwok T, Lau E, Leung P, Woo J . Associated factors and health impact of sarcopenia in older chinese men and women: a cross-sectional study. Gerontology. 2007; 53(6):404-10. DOI: 10.1159/000107355. View

11.

Barrett-Connor E, Khaw K . Cigarette smoking and increased central adiposity. Ann Intern Med. 1989; 111(10):783-7. DOI: 10.7326/0003-4819-111-10-783. View

12.

Flegal K, Troiano R, Pamuk E, Kuczmarski R, Campbell S . The influence of smoking cessation on the prevalence of overweight in the United States. N Engl J Med. 1995; 333(18):1165-70. DOI: 10.1056/NEJM199511023331801. View

13.

Stookey G, Katz B, Olson B, Drook C, Cohen S . Evaluation of biochemical validation measures in determination of smoking status. J Dent Res. 1987; 66(10):1597-601. DOI: 10.1177/00220345870660101801. View

14.

Oncken C, Cooney J, Feinn R, Lando H, Kranzler H . Transdermal nicotine for smoking cessation in postmenopausal women. Addict Behav. 2006; 32(2):296-309. DOI: 10.1016/j.addbeh.2006.04.004. View

15.

Jee S, Lee S, Nam C, Kim S, Kim M . Effect of smoking on the paradox of high waist-to-hip ratio and low body mass index. Obes Res. 2002; 10(9):891-5. DOI: 10.1038/oby.2002.122. View

16.

Kenny D, Calsyn R, Morse G, Klinkenberg W, Winter J, Trusty M . Evaluation of treatment programs for persons with severe mental illness: moderator and mediator effects. Eval Rev. 2004; 28(4):294-324. DOI: 10.1177/0193841X04264701. View

17.

Bamia C, Trichopoulou A, Lenas D, Trichopoulos D . Tobacco smoking in relation to body fat mass and distribution in a general population sample. Int J Obes Relat Metab Disord. 2004; 28(8):1091-6. DOI: 10.1038/sj.ijo.0802697. View

18.

Stavropoulos-Kalinoglou A, Metsios G, Panoulas V, Douglas K, Nevill A, Jamurtas A . Cigarette smoking associates with body weight and muscle mass of patients with rheumatoid arthritis: a cross-sectional, observational study. Arthritis Res Ther. 2008; 10(3):R59. PMC: 2483449. DOI: 10.1186/ar2429. View

19.

French S, Jeffery R, Klesges L, Forster J . Weight concerns and change in smoking behavior over two years in a working population. Am J Public Health. 1995; 85(5):720-2. PMC: 1615425. DOI: 10.2105/ajph.85.5.720. View

20.

Oncken C, Prestwood K, Cooney J, Unson C, Fall P, Kulldorff M . Effects of smoking cessation or reduction on hormone profiles and bone turnover in postmenopausal women. Nicotine Tob Res. 2003; 4(4):451-8. DOI: 10.1080/1462220021000018399. View