Analysis of P53 Mutation and Invasion Front Grading in Oral Squamous Cell Carcinomas

Overview

Journal J Huazhong Univ Sci Technolog Med Sci

Specialty General Medicine

Date 2010 Aug 18

PMID 20714883

Citations 4

Authors

Sanbao Tang

Dongxuan Xu

Bin Zhou

Affiliations

Soon will be listed here.

Abstract

We examined P53 mutation and invasion front grading (IFG) in 30 cases of oral squamous cell carcinomas (OSCCs). The association of P53 mutation and IFG scores with clinicopathological parameters was evaluated. P53 mutation existed in exon 5-8 in 15 out of the 30 OSCCs (50%). The incidence of P53 mutation was not associated with age, gender, N value and TNM stage. However, there was a significant correlation between P53 mutation and T value (P=0.046). There were no statistically significant correlations among the clinicopathological parameters and IFG. Interestingly, The IFG score in OSCCs with P53 mutation was significantly higher than that in OSCCs without P53 mutation (P<0.001). These results suggest that the high incidence of P53 mutation is a major mechanism of OSCC carcinogenesis. The presence of P53 mutation indicates the most anaplastic fields in the invasive areas of the tumors, which may predict poor prognosis for the patients.

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