Choroidal Neovascularization Due to Punctate Inner Choroidopathy: Long-term Follow-up and Review of Literature

Overview

Journal Clin Ophthalmol

Publisher Dove Medical Press

Specialty Ophthalmology

Date 2010 Aug 18

PMID 20714365

Citations 4

Authors

Dimitrios Brouzas

Antonios Charakidas

Tryfon Rotsos

Marilita M Moschos

Helen Loukianou

Chryssanthy Koutsandrea

Ioannis Ladas

Stefanos Baltatzis

Affiliations

Soon will be listed here.

Abstract

Introduction: The aim of the article was to report on the long-term follow-up of choroidal neovascularization (CNV) cases secondary to punctate inner choroidopathy (PIC) either treated with photodynamic therapy (PDT) or followed without treatment. A comprehensive review of existing literature on the various treatment modalities is incorporated.

Methods: Nine eyes of 8 female patients with CNV due to PIC were followed retrospectively for an average of 105 months (range, 36-162 months). Mean age of the patient cohort on presentation was 28 years (range, 21-39). Four eyes were treated with PDT, whereas in 4 patients, including 1 with bilateral involvement, the disease followed its natural course without treatment. Snellen visual acuity and the extent of neovascularization and subretinal fibrosis were evaluated on presentation and at the end of the follow-up period.

Results: Improvement of vision was observed in 6 eyes (66.7%), including all cases treated with PDT, and in 2 of 5 eyes left untreated. The size of the neovascular lesion, including both CNV and subretinal fibrosis, increased in all cases left untreated (55.6%) and remained stable in all cases treated with PDT (44.4%).

Conclusion: Without treatment, the CNV due to PIC is slowly progressive. Our short cohort appears to have benefited from PDT in terms of maintaining visual acuity and stabilizing the extent of CNV and fibrosis.

Citing Articles

Two-Year Outcome of Aflibercept for the Treatment of Choroidal Neovascularization in Punctate Inner Choroidopathy.

Arrevola L, Acero M, Peral M Case Rep Ophthalmol. 2019; 10(1):24-31.

PMID: 31043958 PMC: 6477474. DOI: 10.1159/000496143.

Choroidal Neovascularization Associated with Punctate Inner Choroidopathy: Combination of Intravitreal Anti-VEGF and Systemic Immunosuppressive Therapy.

Hohberger B, Rudolph M, Bergua A Case Rep Ophthalmol. 2016; 6(3):385-9.

PMID: 26955337 PMC: 4777951. DOI: 10.1159/000441694.

Punctate inner choroidopathy: a systematic review.

Campos J, Campos A, Mendes S, Neves A, Beselga D, Sousa J Med Hypothesis Discov Innov Ophthalmol. 2015; 3(3):76-82.

PMID: 25741523 PMC: 4348489.

Punctate inner choroidopathy: a clinical case report.

Campos J, Campos A, Beselga D, Mendes S, Neves A, Castro Sousa J Case Rep Ophthalmol. 2013; 4(3):155-9.

PMID: 24163685 PMC: 3806698. DOI: 10.1159/000355389.

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