Social Play Impairment Following Status Epilepticus During Early Development

Overview

Journal J Neural Transm (Vienna)

Specialties Neurology
Physiology

Date 2010 Aug 17

PMID 20711791

Citations 9

Authors

Adelisandra Silva Santos Castelhano

Fulvio Alexandre Scorza

Maria Cristina Triguero Veloz Teixeira

Ricardo Mario Arida

Esper Abrao Cavalheiro

Roberta Monterazzo Cysneiros

Affiliations

Soon will be listed here.

Abstract

Neonatal status epilepticus (SE) disrupts prefrontal cortex and thalamus, brain regions related to social play. Juvenile play was evaluated using the "intruder-resident" paradigm following SE in 9-day-old Wistar pups of both genders. Quite interestingly, we demonstrated for the first time that neonatal SE produces social impairment in male rats, reduces locomotor activity in both genders and enhances self-grooming in female. Additional studies are necessary to clarify if these effects can impair social behavior across the life span.

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