Cytokinesis Through Biochemical-mechanical Feedback Loops

Overview

Journal Semin Cell Dev Biol

Specialties Cell Biology
Reproductive Medicine

Date 2010 Aug 17

PMID 20709619

Citations 23

Authors

Alexandra Surcel

Yee-Seir Kee

Tianzhi Luo

Douglas N Robinson

Affiliations

Soon will be listed here.

Abstract

Cytokinesis is emerging as a control system defined by interacting biochemical and mechanical modules, which form a system of feedback loops. This integrated system accounts for the regulation and kinetics of cytokinesis furrowing and demonstrates that cytokinesis is a whole-cell process in which the global and equatorial cortices and cytoplasm are active players in the system. Though originally defined in Dictyostelium, features of the control system are recognizable in other organisms, suggesting a universal mechanism for cytokinesis regulation and contractility.

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