Intragenic Recombination As a Mechanism of Genetic Diversity in Bluetongue Virus

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 2010 Aug 13

PMID 20702614

Citations 26

Authors

Cheng-Qiang He

Nai-Zheng Ding

Mei He

Shan-Ni Li

Xing-Ming Wang

Hong-Bin He

Xin-Fa Liu

Hong-Shan Guo

Affiliations

Soon will be listed here.

Abstract

Bluetongue (BT), caused by Bluetongue virus (BTV), is an economically important disease affecting sheep, deer, cattle, and goats. Since 1998, a series of BT outbreaks have spread across much of southern and central Europe. To study why the epidemiology of the virus happens to change, it is important to fully know the mechanisms resulting in its genetic diversity. Gene mutation and segment reassortment have been considered as the key forces driving the evolution of BTV. However, it is still unknown whether intragenic recombination can occur and contribute to the process in the virus. We present here several BTV groups containing mosaic genes to reveal that intragenic recombination can take place between the virus strains and play a potential role in bringing novel BTV lineages.

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