Ghrelin and Metabolic Surgery

Overview

Journal Int J Pept

Date 2010 Aug 12

PMID 20700402

Citations 17

Authors

Dimitrios J Pournaras

Carel W le Roux

Affiliations

Soon will be listed here.

Abstract

Metabolic surgery is the most effective treatment for morbid obesity. Ghrelin has been implicated to play a role in the success of these procedures. Furthermore, these operations have been used to study the gut-brain axis. This article explores this interaction, reviewing the available data on changes in ghrelin levels after different surgical procedures.

Citing Articles

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References

Sundbom M, Holdstock C, Engstrom B, Anders Karlsson F . Early changes in ghrelin following Roux-en-Y gastric bypass: influence of vagal nerve functionality?. Obes Surg. 2007; 17(3):304-10. DOI: 10.1007/s11695-007-9056-8. View

Valera Mora M, Manco M, Capristo E, Guidone C, Iaconelli A, Gniuli D . Growth hormone and ghrelin secretion in severely obese women before and after bariatric surgery. Obesity (Silver Spring). 2007; 15(8):2012-8. DOI: 10.1038/oby.2007.240. View

Korner J, Bessler M, Cirilo L, Conwell I, Daud A, Restuccia N . Effects of Roux-en-Y gastric bypass surgery on fasting and postprandial concentrations of plasma ghrelin, peptide YY, and insulin. J Clin Endocrinol Metab. 2004; 90(1):359-65. DOI: 10.1210/jc.2004-1076. View

le Roux C, Neary N, Halsey T, Small C, Martinez-Isla A, Ghatei M . Ghrelin does not stimulate food intake in patients with surgical procedures involving vagotomy. J Clin Endocrinol Metab. 2005; 90(8):4521-4. DOI: 10.1210/jc.2004-2537. View

Kotidis E, Koliakos G, Papavramidis T, Papavramidis S . The effect of biliopancreatic diversion with pylorus-preserving sleeve gastrectomy and duodenal switch on fasting serum ghrelin, leptin and adiponectin levels: is there a hormonal contribution to the weight-reducing effect of this procedure?. Obes Surg. 2006; 16(5):554-9. DOI: 10.1381/096089206776944940. View

McLaughlin T, Abbasi F, Lamendola C, Frayo R, Cummings D . Plasma ghrelin concentrations are decreased in insulin-resistant obese adults relative to equally obese insulin-sensitive controls. J Clin Endocrinol Metab. 2004; 89(4):1630-5. DOI: 10.1210/jc.2003-031572. View

Parker B, Doran S, Wishart J, Horowitz M, Chapman I . Effects of small intestinal and gastric glucose administration on the suppression of plasma ghrelin concentrations in healthy older men and women. Clin Endocrinol (Oxf). 2005; 62(5):539-46. DOI: 10.1111/j.1365-2265.2005.02254.x. View

Whitson B, Leslie D, Kellogg T, Maddaus M, Buchwald H, Billington C . Entero-endocrine changes after gastric bypass in diabetic and nondiabetic patients: a preliminary study. J Surg Res. 2007; 141(1):31-9. DOI: 10.1016/j.jss.2007.02.022. View

Karamanakos S, Vagenas K, Kalfarentzos F, Alexandrides T . Weight loss, appetite suppression, and changes in fasting and postprandial ghrelin and peptide-YY levels after Roux-en-Y gastric bypass and sleeve gastrectomy: a prospective, double blind study. Ann Surg. 2008; 247(3):401-7. DOI: 10.1097/SLA.0b013e318156f012. View

10.

Wren A, Seal L, Cohen M, Brynes A, Frost G, Murphy K . Ghrelin enhances appetite and increases food intake in humans. J Clin Endocrinol Metab. 2001; 86(12):5992. DOI: 10.1210/jcem.86.12.8111. View

11.

Cohen R, Uzzan B, Bihan H, Khochtali I, Reach G, Catheline J . Ghrelin levels and sleeve gastrectomy in super-super-obesity. Obes Surg. 2005; 15(10):1501-2. DOI: 10.1381/096089205774859335. View

12.

Ybarra J, Bobbioni-Harsch E, Chassot G, Huber O, Morel P, Assimacopoulos-Jeannet F . Persistent correlation of ghrelin plasma levels with body mass index both in stable weight conditions and during gastric-bypass-induced weight loss. Obes Surg. 2008; 19(3):327-31. DOI: 10.1007/s11695-008-9748-8. View

13.

le Roux C, Aylwin S, Batterham R, Borg C, Coyle F, Prasad V . Gut hormone profiles following bariatric surgery favor an anorectic state, facilitate weight loss, and improve metabolic parameters. Ann Surg. 2005; 243(1):108-14. PMC: 1449984. DOI: 10.1097/01.sla.0000183349.16877.84. View

14.

Couce M, Cottam D, Esplen J, Schauer P, Burguera B . Is ghrelin the culprit for weight loss after gastric bypass surgery? A negative answer. Obes Surg. 2006; 16(7):870-8. DOI: 10.1381/096089206777822151. View

15.

Dixon A, Dixon J, OBrien P . Laparoscopic adjustable gastric banding induces prolonged satiety: a randomized blind crossover study. J Clin Endocrinol Metab. 2004; 90(2):813-9. DOI: 10.1210/jc.2004-1546. View

16.

Lin E, Gletsu N, Fugate K, McClusky D, Gu L, Zhu J . The effects of gastric surgery on systemic ghrelin levels in the morbidly obese. Arch Surg. 2004; 139(7):780-4. DOI: 10.1001/archsurg.139.7.780. View

17.

Foschi D, Corsi F, Colombo F, Vago T, Bevilaqua M, Rizzi A . Different effects of vertical banded gastroplasty and Roux-en-Y gastric bypass on meal inhibition of ghrelin secretion in morbidly obese patients. J Invest Surg. 2008; 21(2):77-81. DOI: 10.1080/08941930701883624. View

18.

Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K . Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature. 1999; 402(6762):656-60. DOI: 10.1038/45230. View

19.

Vendrell J, Broch M, Vilarrasa N, Molina A, Gomez J, Gutierrez C . Resistin, adiponectin, ghrelin, leptin, and proinflammatory cytokines: relationships in obesity. Obes Res. 2004; 12(6):962-71. DOI: 10.1038/oby.2004.118. View

20.

Pournaras D, le Roux C . Obesity, gut hormones, and bariatric surgery. World J Surg. 2009; 33(10):1983-8. DOI: 10.1007/s00268-009-0080-9. View