Multi-projection Fluorescence Optical Tomography Using a Handheld-probe-based Optical Imager: Phantom Studies

Overview

Journal Appl Opt

Date 2010 Aug 11

PMID 20697435

Citations 1

Authors

Jiajia Ge

Sarah J Erickson

Anuradha Godavarty

Affiliations

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Abstract

A handheld-probe-based optical imager has recently been developed toward three-dimensional tomography. In this study, the improvement of target depth recovery was demonstrated using a multi-projection technique on large slab phantoms using 0.45 cc fluorescing target(s) (with 1:0 contrast ratio) of 1.5 to 2.5 cm deep. Tomographic results using single- and multi- (here dual) projection measurements (with and without a priori information of target location) were compared. In all experimental cases, the use of multi-projection measurements along with a priori information recovered target depth and location closer to their true values, demonstrating its applicability for clinical translation.

Citing Articles

Three-dimensional fluorescence tomography of human breast tissues in vivo using a hand-held optical imager.

Erickson S, Martinez S, DeCerce J, Romero A, Caldera L, Godavarty A Phys Med Biol. 2013; 58(5):1563-79.

PMID: 23417060 PMC: 3619223. DOI: 10.1088/0031-9155/58/5/1563.

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