T-cell Receptor Complex is Essential for Fas Signal Transduction

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 2010 Aug 11

PMID 20696918

Citations 21

Authors

Askar M Akimzhanov

Xinmin Wang

Jiaren Sun

Darren Boehning

Affiliations

Soon will be listed here.

Abstract

The Fas receptor (also known as CD95 and APO-1) is a member of the tumor necrosis factor alpha-family of death receptors that mediate T-cell responses. Here, we show that Fas receptor signaling requires a functional T-cell receptor (TCR) complex. Fas receptor directly binds to and activates TCR components in a stimulus-dependent manner. Fas receptor stimulation does not activate canonical downstream TCR pathways, but instead the TCR complex is required specifically for Fas-mediated calcium release. Importantly, null mutations in Lck, ZAP70, and the TCR alpha- and beta-chains abrogate Fas signaling. Our results reveal a direct role for the TCR complex in mediating Fas-specific signaling events critical for T-cell homeostasis.

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