The Impact of Genetic Research on Our Understanding of Parkinson's Disease

Overview

Journal Prog Brain Res

Publisher Elsevier

Specialty Neurology

Date 2010 Aug 11

PMID 20696313

Citations 18

Authors

Ian Martin

Valina L Dawson

Ted M Dawson

Affiliations

Soon will be listed here.

Abstract

Until recently, genetics was thought to play a minor role in the development of Parkinson's disease (PD). Over the last decade, a number of genes that definitively cause PD have been identified, which has led to the generation of disease models based on pathogenic gene variants that recapitulate many features of the disease. These genetic studies have provided novel insight into potential mechanisms underlying the aetiology of PD. This chapter will provide a profile of the genes conclusively linked to PD and will outline the mechanisms of PD pathogenesis implicated by genetic studies. Mitochondrial dysfunction, oxidative stress and impaired ubiquitin-proteasome system function are disease mechanisms that are particularly well supported by genetic studies and are therefore the focus of this chapter.

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