Repeated Administrations of Carbon Nanotubes in Male Mice Cause Reversible Testis Damage Without Affecting Fertility

Overview

Journal Nat Nanotechnol

Specialty Biotechnology

Date 2010 Aug 10

PMID 20693989

Citations 67

Authors

Yuhong Bai

Yi Zhang

Jingping Zhang

Qingxin Mu

Weidong Zhang

Elizabeth R Butch

Scott E Snyder

Bing Yan

Affiliations

Soon will be listed here.

Abstract

Soluble carbon nanotubes show promise as materials for in vivo delivery and imaging applications. Several reports have described the in vivo toxicity of carbon nanotubes, but their effects on male reproduction have not been examined. Here, we show that repeated intravenous injections of water-soluble multiwalled carbon nanotubes into male mice can cause reversible testis damage without affecting fertility. Nanotubes accumulated in the testes, generated oxidative stress and decreased the thickness of the seminiferous epithelium in the testis at day 15, but the damage was repaired at 60 and 90 days. The quantity, quality and integrity of the sperm and the levels of three major sex hormones were not significantly affected throughout the 90-day period. The fertility of treated male mice was unaffected; the pregnancy rate and delivery success of female mice that mated with the treated male mice did not differ from those that mated with untreated male mice.

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