Role of Tissue Factor in Venous Thrombosis

Overview

Journal Annu Rev Physiol

Publisher Annual Reviews

Specialty Physiology

Date 2010 Aug 10

PMID 20690821

Citations 49

Authors

David A Manly

Jeremiah Boles

Nigel Mackman

Affiliations

Soon will be listed here.

Abstract

Venous thromboembolism (VTE) is a leading cause of morbidity and mortality worldwide. However, the mechanisms by which clots are formed in the deep veins have not been determined. Tissue factor (TF) is the primary initiator of the coagulation cascade and is essential for hemostasis. Under pathological conditions, TF is released into the circulation on small-membrane vesicles termed microparticles (MPs). Recent studies suggest that elevated levels of MP TF may trigger thrombosis. This review provides an overview of the role of TF in VTE.

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