Antigen Receptor Signaling to NF-kappaB Via CARMA1, BCL10, and MALT1

Overview

Journal Cold Spring Harb Perspect Biol

Specialties Biology
Molecular Biology

Date 2010 Aug 6

PMID 20685844

Citations 128

Authors

Margot Thome

Jean Enno Charton

Christiane Pelzer

Stephan Hailfinger

Affiliations

Soon will be listed here.

Abstract

The signaling pathway controlling antigen receptor-induced regulation of the transcription factor NF-kappaB plays a key role in lymphocyte activation and development and the generation of lymphomas. Work of the past decade has led to dramatic progress in the identification and characterization of new players in the pathway. Moreover, novel enzymatic activities relevant for this pathway have been discovered, which represent interesting drug targets for immuno-suppression or lymphoma treatment. Here, we summarize these findings and give an outlook on interesting open issues that need to be addressed in the future.

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References

Hara H, Wada T, Bakal C, Kozieradzki I, Suzuki S, Suzuki N . The MAGUK family protein CARD11 is essential for lymphocyte activation. Immunity. 2003; 18(6):763-75. DOI: 10.1016/s1074-7613(03)00148-1. View

Isaacson P, Du M . MALT lymphoma: from morphology to molecules. Nat Rev Cancer. 2004; 4(8):644-53. DOI: 10.1038/nrc1409. View

Thome M . CARMA1, BCL-10 and MALT1 in lymphocyte development and activation. Nat Rev Immunol. 2004; 4(5):348-59. DOI: 10.1038/nri1352. View

Matsumoto R, Wang D, Blonska M, Li H, Kobayashi M, Pappu B . Phosphorylation of CARMA1 plays a critical role in T Cell receptor-mediated NF-kappaB activation. Immunity. 2005; 23(6):575-85. DOI: 10.1016/j.immuni.2005.10.007. View

Egawa T, Albrecht B, Favier B, Sunshine M, Mirchandani K, OBrien W . Requirement for CARMA1 in antigen receptor-induced NF-kappa B activation and lymphocyte proliferation. Curr Biol. 2003; 13(14):1252-8. DOI: 10.1016/s0960-9822(03)00491-3. View

Sixt M, Bauer M, Lammermann T, Fassler R . Beta1 integrins: zip codes and signaling relay for blood cells. Curr Opin Cell Biol. 2006; 18(5):482-90. DOI: 10.1016/j.ceb.2006.08.007. View

Snipas S, Wildfang E, Nazif T, Christensen L, Boatright K, Bogyo M . Characteristics of the caspase-like catalytic domain of human paracaspase. Biol Chem. 2004; 385(11):1093-8. DOI: 10.1515/BC.2004.142. View

Duwel M, Welteke V, Oeckinghaus A, Baens M, Kloo B, Ferch U . A20 negatively regulates T cell receptor signaling to NF-kappaB by cleaving Malt1 ubiquitin chains. J Immunol. 2009; 182(12):7718-28. DOI: 10.4049/jimmunol.0803313. View

Yan M, Lee J, Schilbach S, Goddard A, Dixit V . mE10, a novel caspase recruitment domain-containing proapoptotic molecule. J Biol Chem. 1999; 274(15):10287-92. DOI: 10.1074/jbc.274.15.10287. View

10.

Schulze-Luehrmann J, Ghosh S . Antigen-receptor signaling to nuclear factor kappa B. Immunity. 2006; 25(5):701-15. DOI: 10.1016/j.immuni.2006.10.010. View

11.

Lee K, DAcquisto F, Hayden M, Shim J, Ghosh S . PDK1 nucleates T cell receptor-induced signaling complex for NF-kappaB activation. Science. 2005; 308(5718):114-8. DOI: 10.1126/science.1107107. View

12.

Thome M, Weil R . Post-translational modifications regulate distinct functions of CARMA1 and BCL10. Trends Immunol. 2007; 28(6):281-8. DOI: 10.1016/j.it.2007.04.004. View

13.

Rawlings D, Sommer K, Moreno-Garcia M . The CARMA1 signalosome links the signalling machinery of adaptive and innate immunity in lymphocytes. Nat Rev Immunol. 2006; 6(11):799-812. DOI: 10.1038/nri1944. View

14.

Ferch U, Kloo B, Gewies A, Pfander V, Duwel M, Peschel C . Inhibition of MALT1 protease activity is selectively toxic for activated B cell-like diffuse large B cell lymphoma cells. J Exp Med. 2009; 206(11):2313-20. PMC: 2768866. DOI: 10.1084/jem.20091167. View

15.

Xue L, Morris S, Orihuela C, Tuomanen E, Cui X, Wen R . Defective development and function of Bcl10-deficient follicular, marginal zone and B1 B cells. Nat Immunol. 2003; 4(9):857-65. DOI: 10.1038/ni963. View

16.

Misra R, Russell J, Koenig A, Hinshaw-Makepeace J, Wen R, Wang D . Caspase-8 and c-FLIPL associate in lipid rafts with NF-kappaB adaptors during T cell activation. J Biol Chem. 2007; 282(27):19365-74. PMC: 4521413. DOI: 10.1074/jbc.M610610200. View

17.

Bonizzi G, Karin M . The two NF-kappaB activation pathways and their role in innate and adaptive immunity. Trends Immunol. 2004; 25(6):280-8. DOI: 10.1016/j.it.2004.03.008. View

18.

Rueda D, Gaide O, Ho L, Lewkowicz E, Niedergang F, Hailfinger S . Bcl10 controls TCR- and FcgammaR-induced actin polymerization. J Immunol. 2007; 178(7):4373-84. DOI: 10.4049/jimmunol.178.7.4373. View

19.

Heyninck K, Beyaert R . A20 inhibits NF-kappaB activation by dual ubiquitin-editing functions. Trends Biochem Sci. 2005; 30(1):1-4. DOI: 10.1016/j.tibs.2004.11.001. View

20.

Rebeaud F, Hailfinger S, Posevitz-Fejfar A, Tapernoux M, Moser R, Rueda D . The proteolytic activity of the paracaspase MALT1 is key in T cell activation. Nat Immunol. 2008; 9(3):272-81. DOI: 10.1038/ni1568. View