Relation of Melatonin to Sleep Architecture in Children with Autism

Overview

Journal J Autism Dev Disord

Publisher Springer

Date 2010 Aug 5

PMID 20683768

Citations 26

Authors

Roberta M Leu

Liya Beyderman

Emmanuel J Botzolakis

Kyla Surdyka

Lily Wang

Beth A Malow

Affiliations

Soon will be listed here.

Abstract

Children with autism often suffer from sleep disturbances, and compared to age-matched controls, have decreased melatonin levels, as indicated by urine levels of the primary melatonin metabolite, 6-sulfatoxymelatonin (6-SM). We therefore investigated the relationship between 6-SM levels and sleep architecture in children with autism spectrum disorders (ASD). Twenty-three children, aged 4-10 years, completed two nights of polysomnography and one overnight urine collection for measurement of urinary 6-SM excretion rate. Parents completed the Children's Sleep Habits Questionnaire. We found that higher urinary 6-SM excretion rates were associated with increased N3 sleep, decreased N2 sleep, and decreased daytime sleepiness. The results warrant further examination to examine the effects of supplemental melatonin on sleep architecture and daytime sleepiness.

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